CAS 3056105-63-3

Formula: C20H22N4O7S

InChI: InChI=1S/C20H22N4O7S/c1-28-14-10-16(29-2)18(17(11-14)30-3)32(26,27)23-19(25)15-7-6-13(20(22-15)31-4)12-24-9-5-8-21-24/h5-11H,12H2,1-4H3,(H,23,25)

InChI key: KZSVPOQXJZQAQQ-UHFFFAOYSA-N

SMILES: COC1=CC(=C(C(=C1)OC)S(=O)(=O)NC(=O)C2=NC(=C(C=C2)CN3C=CC=N3)OC)OC

OP-3136

CAS: 3056105-63-3

OP-3136 is a selective inhibitor of KAT6. It can reduce the proliferation capability of cancer cells and inhibit cell growth in ER+ breast cancer cell models with KAT6 overexpression. When used in combination with ER antagonists/degraders or CDK4/6 inhibitors, OP-3136 exhibits synergistic anti-tumor activity in mouse xenograft models. It is applicable in research related to HR+/HER2- breast cancer.

Formula: C₂₀H₂₂N₄O₇S

Molecular weight: 462.48

Ref: TM-T218567