CAS 3057939-67-7

NA

Formula: C₃₈H₅₇ClN₉O₇P

InChI: InChI=1S/C38H57ClN9O7P/c1-52-33-26-28(11-12-31(33)45-38-43-27-29(39)36(46-38)44-32-9-4-5-10-34(32)56(2,3)51)47-16-18-48(19-17-47)35(49)13-20-53-22-24-55-25-23-54-21-15-42-37(50)30(41)8-6-7-14-40/h4-5,9-12,26-27,30H,6-8,13-25,40-41H2,1-3H3,(H,42,50)(H2,43,44,45,46)/t30-/m0/s1

InChI key: JYXPJKQMTZRTKP-PMERELPUSA-N

SMILES: COC1=C(C=CC(=C1)N2CCN(CC2)C(=O)CCOCCOCCOCCNC(=O)[C@H](CCCCN)N)NC3=NC=C(C(=N3)NC4=CC=CC=C4P(=O)(C)C)Cl

Synonyms:

• [Synonyms]

Lys-PEG3-BA

CAS: 3057939-67-7

Lys-PEG3-BA is a PROTAC degrader targeting EML4-ALK/EGFR, with DC50 values of 1.32 μM for H3122 cells (expressing EML4-ALK fusion protein) and 19.66 μM for H1975 cells (with EGFRL858R/T790M mutations). In vitro studies show that Lys-PEG3-BA can inhibit the proliferation of non-small cell lung cancer cells by modulating the ubiquitin-proteasome system. Lys-PEG3-BA is applicable for research related to non-small cell lung cancer.

Formula: C₃₈H₅₇ClN₉O₇P

Molecular weight: 818.35

Ref: TM-T217126