CAS 3058199-58-6

NA

Formula: C₁₆H₁₄Cl₂DN₅OS₂

InChI: InChI=1S/C16H15Cl2N5OS2/c1-9(24)5-20-14-7-19-13(6-21-14)15-22-23-16(26-15)25-8-10-11(17)3-2-4-12(10)18/h2-4,6-7,9,24H,5,8H2,1H3,(H,20,21)/t9-/m1/s1/i8D/t8?,9-

InChI key: XPQKPOPHNKADDB-ZREHSADESA-N

SMILES: [2H]C(C1=C(C=CC=C1Cl)Cl)SC2=NN=C(S2)C3=CN=C(C=N3)NC[C@@H](C)O

Synonyms:

• [Synonyms]

MCB-22-174

CAS: 3058199-58-6

MCB-22-174 is a potent agonist of Piezo1 with an EC50 value of 6.28 µM. It activates Ca2+-related extracellular signal-regulated kinase and calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) pathways, and it promotes mesenchymal stem cell osteogenic differentiation, indicating its potential application in the study of disuse osteoporosis (OP).

Formula: C₁₆H₁₄DCl₂N₅OS₂

Color and Shape: Solid

Molecular weight: 429.37

Ref: TM-T207793