CAS 3061491-60-6

Formula: C22H24N2O9S

InChI: InChI=1S/C22H24N2O9S/c1-21(2)13-22-12-16(25)23(20(22)29)8-7-17(26)32-9-4-10-33-18(27)14-5-3-6-15(11-14)34(30,31)24(22)19(21)28/h3,5-6,11H,4,7-10,12-13H2,1-2H3

InChI key: FDQMGLAVDNTTTR-UHFFFAOYSA-N

SMILES: CC1(CC23CC(=O)N(C2=O)CCC(=O)OCCCOC(=O)C4=CC(=CC=C4)S(=O)(=O)N3C1=O)C

SIRT3 activator 2

CAS: 3061491-60-6

SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.

Formula: C₂₂H₂₄N₂O₉S

Color and Shape: Solid

Molecular weight: 492.5

Ref: TM-T200160