CAS 3065631-84-4

Formula: C17H16F3N5O2

InChI: InChI=1S/C17H16F3N5O2/c1-6-4-5-9(26)7(2)12(6)25-14(21)11(15(22)27)10-13(17(18,19)20)23-8(3)24-16(10)25/h4-5,26H,21H2,1-3H3,(H2,22,27)

InChI key: XFOOQOBHVCPRRK-UHFFFAOYSA-N

SMILES: CC1=C(C(=C(C=C1)O)C)N2C(=C(C3=C(N=C(N=C32)C)C(F)(F)F)C(=O)N)N

PKMYT1-IN-8

CAS: 3065631-84-4

PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1, with an IC₅₀ value of 9 nM. It also inhibits EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3, and EPHB2, exhibiting IC₅₀ values of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10, and 10.9 μM, respectively. Additionally, PKMYT1-IN-8 suppresses the proliferation of cancer cells OVCAR3 with a GI50 of 2.02 μM.

Formula: C₁₇H₁₆F₃N₅O₂

Color and Shape: Solid

Molecular weight: 379.336

Ref: TM-T204125