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CAS 3068378-38-8

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  • GSK3β-IN-2
    Targetmol
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    GSK3β-IN-2

    CAS:
    GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.
    Formula:C25H18N4O
    Color and Shape:Solid
    Molecular weight:390.437

    Ref: TM-T205461