CAS 3068378-38-8

Formula: C25H18N4O

InChI: InChI=1S/C25H18N4O/c30-25(29-23-16-26-12-11-20(23)18-9-5-2-6-10-18)22-15-28-24-21(22)13-19(14-27-24)17-7-3-1-4-8-17/h1-16H,(H,27,28)(H,29,30)

InChI key: AZROWJKGAIMYRD-UHFFFAOYSA-N

SMILES: C1=CC=C(C=C1)C2=C(C=NC=C2)NC(=O)C3=CNC4=C3C=C(C=N4)C5=CC=CC=C5

GSK3β-IN-2

CAS: 3068378-38-8

GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.

Formula: C₂₅H₁₈N₄O

Color and Shape: Solid

Molecular weight: 390.437

Ref: TM-T205461