CAS 3069915-36-9

Formula: C17H14ClNO3

InChI: InChI=1S/C17H14ClNO3/c1-19-15-9-14(7-4-12(15)8-16(20)17(19)21)22-10-11-2-5-13(18)6-3-11/h2-9,20H,10H2,1H3

InChI key: WHURMKVVBUVXES-UHFFFAOYSA-N

SMILES: CN1C2=C(C=CC(=C2)OCC3=CC=C(C=C3)Cl)C=C(C1=O)O

MAO-B-IN-45

CAS: 3069915-36-9

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. It selectively inhibits MAO-B with an IC50 of 87.47 nM, demonstrating a selectivity over MAO-A by more than 229 times. In vitro, MAO-B-IN-45 exhibits significant anti-ferroptosis activity by modulating iron metabolism pathways and the GSH-GPX4 axis. Additionally, it improves cognitive and behavioral deficits in 3×Tg (APP/Tau/Ps1) Alzheimer's disease mice and significantly reduces levels of ferritin heavy chain 1 (FTH1), β-amyloid protein (APP), and Tau protein phosphorylation (p-Tau) in their brains.

Formula: C₁₇H₁₄ClNO₃

Color and Shape: Solid

Molecular weight: 315.75

Ref: TM-T211128