CAS 3069940-37-7

Formula: C38H38Cl2N10O6

InChI: InChI=1S/C38H38Cl2N10O6/c39-26-5-2-6-27(40)32(26)46-33(52)25-19-42-38(47-35(25)56-23-8-9-23)44-21-18-43-49(20-21)22-12-16-48(17-13-22)15-3-14-41-28-7-1-4-24-31(28)37(55)50(36(24)54)29-10-11-30(51)45-34(29)53/h1-2,4-7,18-20,22-23,29,41H,3,8-17H2,(H,46,52)(H,42,44,47)(H,45,51,53)

InChI key: KCFSYTXGBLUVSJ-UHFFFAOYSA-N

SMILES: C1CC1OC2=NC(=NC=C2C(=O)NC3=C(C=CC=C3Cl)Cl)NC4=CN(N=C4)C5CCN(CC5)CCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O

WEE1-IN-12

CAS: 3069940-37-7

WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. It inhibits the proliferation of HT29 cells (IC50: 1.07 μM) and shows enhanced efficacy when combined with Gemcitabine (IC50: 0.34 μM). WEE1-IN-12 is applicable in the study of tumors such as colon cancer.

Formula: C₃₈H₃₈Cl₂N₁₀O₆

Molecular weight: 801.68

Ref: TM-T210645