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CAS 3070346-91-4

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  • R1-ICR-5
    Targetmol
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    R1-ICR-5

    CAS:
    <p>R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1). Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.</p>
    Formula:C54H70N8O7S2
    Color and Shape:Solid
    Molecular weight:1007.31

    Ref: TM-T206654