CAS 3075541-07-7

Formula: C24H22N6O2

InChI: InChI=1S/C24H22N6O2/c1-29-15-17(13-26-29)16-9-10-30-21(14-25-24(30)11-16)19-5-4-6-23(27-19)28-20-8-7-18(31-2)12-22(20)32-3/h4-15H,1-3H3,(H,27,28)

InChI key: CFCAHQYNMKPMRM-UHFFFAOYSA-N

SMILES: CN1C=C(C=N1)C2=CC3=NC=C(N3C=C2)C4=NC(=CC=C4)NC5=C(C=C(C=C5)OC)OC

FLT3-IN-40

CAS: 3075541-07-7

FLT3-IN-40 (compound 1) is a type I ATP-competitive FLT3 inhibitor with an IC₅₀ of 16.26 nM. It reduces the autophosphorylation levels of FLT3 and the phosphorylation levels of downstream ERK. FLT3-IN-40 exhibits antiproliferative activity, cell cycle regulation, and apoptosis induction. It is applicable in research related to acute myeloid leukemia.

Formula: C₂₄H₂₂N₆O₂

Molecular weight: 426.47

Ref: TM-T218483