CAS 3076807-15-0
:Formula:C20H16N4O3S
InChI:InChI=1S/C20H16N4O3S/c21-10-24-6-5-14(9-24)19(25)23-20-22-15-7-12(2-4-18(15)28-20)13-1-3-16-17(8-13)27-11-26-16/h1-4,7-8,14H,5-6,9,11H2,(H,22,23,25)/t14-/m0/s1
InChI key:XCXRUESWMUGMHJ-AWEZNQCLSA-N
SMILES:C1CN(C[C@H]1C(=O)NC2=NC3=C(S2)C=CC(=C3)C4=CC5=C(C=C4)OCO5)C#N
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WWQ-03-012
CAS:WWQ-03-012 is a selective inhibitor of deSUMOylating isopeptidase DESI2, with an IC50 of 47.3 μM. It induces ubiquitination-proteasome degradation of JAK2-V617F without significantly affecting wild-type JAK2. This compound can disrupt the JAK2-STAT3/5 signaling pathway, inhibit cell proliferation, and induce apoptosis. When used in combination with Ruxolitinib, WWQ-03-012 demonstrates a synergistic effect, enhancing cytotoxicity against JAK2 mutant cells. It is applicable in cancer research, specifically in studying myeloproliferative neoplasms.Formula:C20H16N4O3SMolecular weight:392.43
