CAS 3086979-57-6

Formula: C35H40N8O6S

InChI: InChI=1S/C35H40N8O6S/c36-29(44)18-17-26(43-35(48)49-21-23-12-5-2-6-13-23)31(46)41-27(20-22-10-3-1-4-11-22)32(47)40-25(15-9-19-39-34(37)38)30(45)33-42-24-14-7-8-16-28(24)50-33/h1-8,10-14,16,25-27H,9,15,17-21H2,(H2,36,44)(H,40,47)(H,41,46)(H,43,48)(H4,37,38,39)/t25-,26-,27-/m0/s1

InChI key: NHRGVOPRIIGWKS-QKDODKLFSA-N

SMILES: C1=CC=C(C=C1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)C2=NC3=CC=CC=C3S2)NC(=O)[C@H](CCC(=O)N)NC(=O)OCC4=CC=CC=C4

Cbz-QFR-kbt

CAS: 3086979-57-6

Cbz-QFR-kbt is a ketobenzothiazolone-based TMPRSS2 inhibitor with an IC₅₀ of 0.42 nM. It also exhibits inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC₅₀ values of 1, 1.3, 85, and 85 nM, respectively. Furthermore, Cbz-QFR-kbt demonstrates significant inhibitory effects on SARS-CoV-2 and H1N1 (IC₅₀= 60 nM) and is applicable for antiviral research.

Formula: C₃₅H₄₀N₈O₆S

Molecular weight: 700.82

Ref: TM-T214146