CAS 3094-09-5

Doxifluridine

Description:

Doxifluridine, with the CAS number 3094-09-5, is a fluorinated pyrimidine analog primarily used in cancer therapy. It is structurally related to the nucleoside thymidine and functions as an antimetabolite, inhibiting DNA synthesis by interfering with the action of thymidylate synthase. This mechanism makes it particularly effective against rapidly dividing cancer cells. Doxifluridine is typically administered in its prodrug form, which is converted into its active metabolite within the body. The compound exhibits a relatively low toxicity profile compared to other chemotherapeutic agents, making it a valuable option in combination therapies for various malignancies. In terms of physical properties, Doxifluridine is a white to off-white crystalline powder, soluble in water, and has a moderate molecular weight. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its therapeutic efficacy. Overall, Doxifluridine represents an important tool in the oncological pharmacotherapy arsenal, particularly for gastrointestinal cancers.

Formula: C₉H₁₁FN₂O₅

InChI: InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1

InChI key: InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N

SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2

Synonyms:

• (2Xi)-5'-Deoxy-5-Fluorouridine
• 5'-Deoxy-5-fluorouridine
• 5'-Dfur
• 5-Fluoro-5'-deoxyuridine
• 5-Fluorodesoxyuridine
• 5′-dFUrd
• Flutron
• Fulturon
• Furtulon
• Ro 21-9738
• Uridine, 5′-deoxy-5-fluoro-
• Doxifluridine
• 5Urd, 5-Fluoro-5deoxyuridine
• Doxifluridine (furtulon)
• 5'-Deoxy-fluorouridine(DFUR)/Doxifluridine
• (+)-5-FLUORO-5'-DEOXYURIDINE 97%
• 5'-DEOXYFLUOROURIDINE
• 5-FLURO-5’-DEOXYURIDINE
• DOXIFLUIRDINE
• 5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738
• Doxifluidine
• DOXIFLURIDINE(SUBJECTTOPATENTFREE)

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 246.19

Ref: 3B-D3579

Capecitabine EP Impurity B

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Molecular weight: 246.19

Ref: ST-EA-CP-C52002

CAPECITABINE IMPURITY B CRS

CAS: 3094-09-5

CAPECITABINE IMPURITY B CRS

Formula: C₁₅H₂₂FN₃O₆

Molecular weight: 359.3501

Ref: 41-Y0001644

Capecitabine Related Compound B (5'-deoxy-5-fluorouridine)

CAS: 3094-09-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₉H₁₁FN₂O₅

Color and Shape: White Powder

Molecular weight: 246.0652

Ref: 45-1090728

Uridine, 5'-deoxy-5-fluoro-

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 246.1924

Ref: IN-DA0031Q7

Doxifluridine

CAS: 3094-09-5

Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.

Formula: C₉H₁₁FN₂O₅

Purity: 99.47% - 99.86%

Color and Shape: White Solid

Molecular weight: 246.19

Ref: TM-T1600

5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Molecular weight: 251.22

Ref: 4Z-C-355

Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Color and Shape: White To Off-White Solid

Molecular weight: 246.19

Ref: 4Z-C-354

Doxifluridine

CAS: 3094-09-5

Doxifluridine

Purity: ≥98%

Molecular weight: 246.19g/mol

Ref: 54-BUP19641

1-(5-Deoxy-β-D-ribofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (5'-Deoxy-5-fluorouridine)

CAS: 3094-09-5

Color and Shape: Neat

Ref: 86-MM0992.06

(+)-5-Fluoro-5'-deoxyuridine

CAS: 3094-09-5

(+)-5-Fluoro-5'-deoxyuridine

Formula: C₉H₁₁FN₂O₅

Purity: 98%

Color and Shape: white solid

Molecular weight: 246.19g/mol

Ref: 54-PC5775

5-Fluoro-5''-deoxyuridine

CAS: 3094-09-5

Formula: C₉H₁₁FN₂O₅

Molecular weight: 246.19

Ref: 7W-GP7931

5’-Deoxyfluorouridine-13C,15N2

Controlled Product

CAS: 3094-09-5

Applications 5’-Deoxyfluorouridine-13C,15N2 is a compound useful in organic synthesis.

Formula: C₈CH₁₁FN₂O₅

Color and Shape: Neat

Molecular weight: 249.17

Ref: TR-D235727

5’-Deoxy-5-fluorouridine

Controlled Product

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B
Applications 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
References Ingle, J., et al.: Cancer, 67, 886 (1991); Harvey, J., et al.: J. Clin. Oncol., 17, 1474 (1999); Asai-Sato, M., et al.: Int. J. Cancer, 115, 539 (2005); Rastelli, F., et al.: Tumori, 94, 370 (2008);

Formula: C₉H₁₁FN₂O₅

Color and Shape: Neat

Molecular weight: 246.19

Ref: TR-D235725

Doxifluridine

Controlled Product

CAS: 3094-09-5

Impurity USP Capecitabine Related Compound B / Capecitabine EP Impurity B
Applications A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity.
References De Cesare, M., et al.: Cancer Res., 49, 5969 (1994), Di Bartolomeo, M., et al.: Tumori, 81, 147 (1995)

Formula: C₉H₁₁FN₂O₅

Color and Shape: Neat

Molecular weight: 246.19

Ref: TR-D556750

5'-Deoxy-5-fluorouridine

CAS: 3094-09-5

5'-Deoxy-5-fluorouridine (5FU) is a nucleoside that is used in the treatment of cancer. It is an antimetabolite that inhibits the synthesis of DNA, RNA, and proteins by reversibly inhibiting ribonucleotide reductase. 5FU also inhibits epidermal growth factor receptor (EGFR), which leads to apoptosis in cancerous cells. The concentration–time curve for 5FU has been determined using tissue culture and hl-60 cells as biological samples. This drug has been shown to be effective against metastatic colorectal cancer when administered with other chemotherapeutic drugs.

Formula: C₉H₁₁FN₂O₅

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 246.2 g/mol

Ref: 3D-ND02968

Doxifluridine

CAS: 3094-09-5

Purity: 98%

Molecular weight: 246.19

Ref: 10-F787567