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CAS 3094-09-5

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Doxifluridine

Description:
Doxifluridine, with the CAS number 3094-09-5, is a fluorinated pyrimidine analog primarily used in cancer therapy. It is structurally related to the nucleoside thymidine and functions as an antimetabolite, inhibiting DNA synthesis by interfering with the action of thymidylate synthase. This mechanism makes it particularly effective against rapidly dividing cancer cells. Doxifluridine is typically administered in its prodrug form, which is converted into its active metabolite within the body. The compound exhibits a relatively low toxicity profile compared to other chemotherapeutic agents, making it a valuable option in combination therapies for various malignancies. In terms of physical properties, Doxifluridine is a white to off-white crystalline powder, soluble in water, and has a moderate molecular weight. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its therapeutic efficacy. Overall, Doxifluridine represents an important tool in the oncological pharmacotherapy arsenal, particularly for gastrointestinal cancers.
Formula:C9H11FN2O5
InChI:InChI=1/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6?,8?/m1/s1
InChI key:InChIKey=ZWAOHEXOSAUJHY-ZIYNGMLESA-N
SMILES:O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2
Synonyms:
  • (2Xi)-5'-Deoxy-5-Fluorouridine
  • 5'-Deoxy-5-fluorouridine
  • 5'-Dfur
  • 5-Fluoro-5'-deoxyuridine
  • 5-Fluorodesoxyuridine
  • 5′-dFUrd
  • Flutron
  • Fulturon
  • Furtulon
  • Ro 21-9738
  • See more synonyms
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