CAS 309913-83-5: Talmapimod

Description: Talmapimod, also known by its chemical name, is a small molecule inhibitor primarily targeting the p38 mitogen-activated protein kinase (MAPK) pathway. This compound is notable for its role in modulating inflammatory responses and has been investigated for therapeutic applications in various conditions, including autoimmune diseases and cancer. Talmapimod exhibits a specific mechanism of action by inhibiting the phosphorylation of downstream substrates involved in inflammatory signaling. Its chemical structure includes functional groups that contribute to its potency and selectivity for the p38 MAPK enzyme. The substance is typically administered in a clinical setting and has undergone various phases of clinical trials to assess its efficacy and safety profile. As with many investigational drugs, the pharmacokinetics, metabolism, and potential side effects are critical areas of study to ensure its therapeutic viability. Overall, Talmapimod represents a promising avenue in the development of targeted therapies aimed at modulating inflammatory pathways.

Formula: C₂₇H₃₀ClFN₄O₃

InChI: InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1

InChI key: InChIKey=ZMELOYOKMZBMRB-DLBZAZTESA-N

SMILES: O=C(C(=O)N(C)C)C1=CN(C=2C=C(Cl)C(=CC12)C(=O)N3CC(N(CC4=CC=C(F)C=C4)CC3C)C)C

Synonyms:

• 1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-
• 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-1H-indole-3-acetamide
• 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
• Scio 469
• Scios 469
• Talmapimod

1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-

CAS: 309913-83-5

• Formula: C₂₇H₃₀ClFN₄O₃
• Purity: 95%
• Molecular weight: 513.0035

Talmapimod

CAS: 309913-83-5

Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold …

• Formula: C₂₇H₃₀ClFN₄O₃
• Purity: 100% - 98%
• Color and Shape: Solid
• Molecular weight: 513

Scio-469

CAS: 309913-83-5

• Molecular weight: 513.00g/mol

Talmapimod

CAS: 309913-83-5

• Formula: C₂₇H₃₀ClFN₄O₃
• Molecular weight: 513.01

Talmapimod

CAS: 309913-83-5

Inhibitor of p38 MAPK kinase

• Formula: C₂₇H₃₀ClFN₄O₃
• Purity: Min. 95%
• Molecular weight: 513 g/mol

5-(2,6-Dichlorophenyl)-2-((2-fluoro-4-nitrophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

CAS: 309913-83-5

• Formula: C₁₉H₉Cl₂FN₄O₃S
• Color and Shape: Neat
• Molecular weight: 463.269

4-Iodobenzyl-2,6-dimethylpiperazine Talmapimod

CAS: 309913-83-5

• Formula: C₂₇H₃₀ClIN₄O₃
• Color and Shape: Neat
• Molecular weight: 620.91