CAS 309913-83-5

Talmapimod

Description:

Talmapimod, also known by its chemical name, is a small molecule inhibitor primarily targeting the p38 mitogen-activated protein kinase (MAPK) pathway. This compound is notable for its role in modulating inflammatory responses and has been investigated for therapeutic applications in various conditions, including autoimmune diseases and cancer. Talmapimod exhibits a specific mechanism of action by inhibiting the phosphorylation of downstream substrates involved in inflammatory signaling. Its chemical structure includes functional groups that contribute to its potency and selectivity for the p38 MAPK enzyme. The substance is typically administered in a clinical setting and has undergone various phases of clinical trials to assess its efficacy and safety profile. As with many investigational drugs, the pharmacokinetics, metabolism, and potential side effects are critical areas of study to ensure its therapeutic viability. Overall, Talmapimod represents a promising avenue in the development of targeted therapies aimed at modulating inflammatory pathways.

Formula: C₂₇H₃₀ClFN₄O₃

InChI: InChI=1S/C27H30ClFN4O3/c1-16-13-33(17(2)12-32(16)14-18-6-8-19(29)9-7-18)26(35)21-10-20-22(25(34)27(36)30(3)4)15-31(5)24(20)11-23(21)28/h6-11,15-17H,12-14H2,1-5H3/t16-,17+/m0/s1

InChI key: InChIKey=ZMELOYOKMZBMRB-DLBZAZTESA-N

SMILES: C(C(N(C)C)=O)(=O)C=1C=2C(N(C)C1)=CC(Cl)=C(C(=O)N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)C2

Synonyms:

• 1H-Indole-3-acetamide, 6-chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-
• 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-1H-indole-3-acetamide
• 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1-piperazinyl]carbonyl]-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
• Scio 469
• Scios 469
• Talmapimod
• Talmapimod hydrochloride
• TalMapiMod (SCIO-469)
• TALMAPIMOD;SCIO469;SCIO 469
• SCIO 469 - Talmapimod
• Unii-B1E00kq6nt
• SCIO 469 hydrochloride

SCIO 469

CAS: 309913-83-5

Formula: C₂₇H₃₀ClFN₄O₃

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 513.0035

Ref: IN-DA0031UH

Scio-469

CAS: 309913-83-5

Scio-469

Formula: C₂₇H₃₀ClFN₄O₃

Molecular weight: 513.0035

Ref: 54-BISN0291

Talmapimod

CAS: 309913-83-5

Talmapimod (SCIO-469): Oral ATP-competitive p38α inhibitor, IC50 = 9 nM (p38α), 90 nM (p38β), >2000-fold selectivity over 20 kinases.

Formula: C₂₇H₃₀ClFN₄O₃

Purity: 98% - 99.9%

Color and Shape: White Solid

Molecular weight: 513

Ref: TM-T12871

Talmapimod

CAS: 309913-83-5

Formula: C₂₇H₃₀ClFN₄O₃

Molecular weight: 513.01

Ref: 4Z-T-410001

Talmapimod

CAS: 309913-83-5

Ref: BE-RMCT014000

5-(2,6-Dichlorophenyl)-2-((2-fluoro-4-nitrophenyl)thio)-6H-pyrimido[1,6-b]pyridazin-6-one

Controlled Product

CAS: 309913-83-5

Formula: C₁₉H₉Cl₂FN₄O₃S

Color and Shape: Neat

Molecular weight: 463.269

Ref: TR-D005570

4-Iodobenzyl-2,6-dimethylpiperazine Talmapimod

Controlled Product

CAS: 309913-83-5

Formula: C₂₇H₃₀ClIN₄O₃

Color and Shape: Neat

Molecular weight: 620.91

Ref: TR-I005550

Talmapimod

Controlled Product

CAS: 309913-83-5

Inhibitor of p38 MAPK kinase

Formula: C₂₇H₃₀ClFN₄O₃

Purity: Min. 95%

Molecular weight: 513 g/mol

Ref: 3D-FT103944