CAS 3108138-84-4

Formula: C31H40F2N8O5S

InChI: InChI=1S/C31H40F2N8O5S/c1-39-26-17-21(3-4-24(26)28(38-39)25-5-6-27(42)37-29(25)43)20-7-12-40(13-8-20)11-2-16-47(44,45)41-14-9-22(10-15-41)36-31-34-18-23(19-35-31)46-30(32)33/h3-4,17-20,22,25,30H,2,5-16H2,1H3,(H,34,35,36)(H,37,42,43)

InChI key: QZYYXZIHOFCUDB-UHFFFAOYSA-N

SMILES: CN1C2=C(C=CC(=C2)C3CCN(CC3)CCCS(=O)(=O)N4CCC(CC4)NC5=NC=C(C=N5)OC(F)F)C(=N1)C6CCC(=O)NC6=O

PROTAC CDK2/4 Degrader-1

CAS: 3108138-84-4

PROTACCDK2/4 Degrader-1 (Compound 5) is a potent CDK2/4 PROTAC degrader with a DC50 of ≤ 10 nM for both CDK2 and CDK4. It demonstrates excellent activity in inhibiting cell proliferation in OVCAR3 and T47D cell lines. This compound is applicable for breast cancer and ovarian cancer research.

Formula: C₃₁H₄₀F₂N₈O₅S

Molecular weight: 674.77

Ref: TM-T216547