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CAS 3108318-77-7

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    JAK2-IN-18

    CAS:
    JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. It effectively inhibits the JAK-STAT signaling pathway, with an IC50 value of less than 100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 suppresses the proliferation of abnormally proliferating myeloid cells and is useful in research on myeloproliferative disorders, such as essential thrombocythemia.
    Formula:C37H36N8O4
    Molecular weight:656.75

    Ref: TM-T214358

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