CAS 315705-10-3

Formula: C11H10N6S2

InChI: InChI=1S/C11H10N6S2/c1-6-8(19-9(12)15-6)7-5-18-11(16-7)17-10-13-3-2-4-14-10/h2-5H,1H3,(H2,12,15)(H,13,14,16,17)

InChI key: FHVNBKUGDCJKHS-UHFFFAOYSA-N

SMILES: CC1=C(SC(=N1)N)C2=CSC(=N2)NC3=NC=CC=N3

GCN2 activator-1

CAS: 315705-10-3

GCN2 activator-1 (Compound 20) is a GCN2 activator that binds to the ATP pocket of GCN2 and activates it in a GCN1-independent manner. It can stimulate the integrated stress response (ISR) in cells and inhibits PKR with an IC₅₀ of 3.75 µM. GCN2 activator-1 is utilized for research on pulmonary veno-occlusive disease (PVOD).

Formula: C₁₁H₁₀N₆S₂

Molecular weight: 290.367

Ref: TM-T211805