CAS 32222-06-3

Calcitriol

Description:

Calcitriol, with the CAS number 32222-06-3, is the active form of vitamin D3, also known as 1,25-dihydroxyvitamin D3. It is a secosteroid hormone that plays a crucial role in calcium and phosphate metabolism in the body. Calcitriol is characterized by its ability to enhance intestinal absorption of calcium and phosphate, promoting bone health and mineralization. It is synthesized in the kidneys from its precursor, calcidiol, which is produced in the liver from vitamin D3. Calcitriol exerts its biological effects by binding to the vitamin D receptor (VDR), influencing gene expression and cellular functions. It is a fat-soluble compound, which means it is soluble in lipids but not in water, and it has a relatively low molecular weight. Due to its significant role in maintaining calcium homeostasis, calcitriol is often used therapeutically in conditions such as osteoporosis, rickets, and certain types of hypoparathyroidism. Its regulation is tightly controlled by various factors, including parathyroid hormone levels and serum calcium concentrations.

Formula: C₂₇H₄₄O₃

InChI: InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1

InChI key: InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N

SMILES: C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(C)(C)O)C)[H])[H]

Synonyms:

• (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
• (1R,5Z)-5-[(2E)-2-[(1R,7aR)-1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
• (1S,3R)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
• (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
• (1S,3R,5Z,7E,14xi)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
• (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol
• (5Z,7E)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-Triene-1,3,25-Triol
• 1,25-Dihydroxycholecalciferol
• 1,25-Dihydroxyvitamin D
• 1,25-Dihydroxyvitamin D₃
• 1,25-dihydroxyvitamin D3
• 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
• 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[(1R,3aS,7aS)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3S,5Z)-
• 1Alpha,25-Dihydroxycholecalciferol
• 1a,25-Dihydroxyvitamin
• 1alpha,25-Dihydroxyvitamin D3
• 1α,25-(OH)2D3
• 1α,25-(OH)₂D₃
• 1α,25-Dihydroxyvitamin D3
• 1α,25-Dihydroxyvitamin D₃
• 1α,25-Hydroxyl-vitamin D₃
• 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol (1α,3β,5Z,7E)-
• CALCITRIOL Calcitriol
• Calcijex
• Calcitriol
• Dihydroxyvitamin D3
• Dihydroxyvitamin D₃
• Dn 101
• Panbonis
• Ro 21-5535
• Rocaltrol
• Silkis
• Solbone P
• Soltriol
• Topitriol
• Toptriol
• Vitamin D3, 1a,25-Dihydroxy-
• 1α,25-Dihydroxycholecalciferol

CALCITRIOL CRS

CAS: 32222-06-3

CALCITRIOL CRS

Formula: C₂₇H₄₄O₃

Color and Shape: Added Modified

Molecular weight: 416.6365

Ref: 41-C0225000

Calcitriol

CAS: 32222-06-3

Other vitamins and their derivatives, nesoi

Formula: C₂₇H₄₄O₃

Color and Shape: Colorless White Powder

Molecular weight: 416.32905

Ref: 45-1086301

Calcitriol

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Color and Shape: White To Off-White Solid

Molecular weight: 416.65

Ref: 4Z-C-129044

Calcitriol

CAS: 32222-06-3

Calcitriol

Formula: C₂₇H₄₄O₃

Purity: 98%

Color and Shape: white solid

Molecular weight: 416.64g/mol

Ref: 54-BIC3222

Calcitriol

CAS: 32222-06-3

Calcitriol

Purity: ≥98%

Molecular weight: 416.64g/mol

Ref: 54-BUP09982

Calcitriol

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Purity: ≥ 97.0%

Color and Shape: White to off-white crystalline powder or crystals

Molecular weight: 416.64

Ref: 7W-GP9482

1a,25-dihydroxy Vitamin D3

CAS: 32222-06-3

Formula: C27H44O3

Purity: >97%

Color and Shape: Solid

Molecular weight: 416.64

Ref: 48-60-1475

Calcitrol 100 µg/mL in Acetonitrile

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Color and Shape: Single Solution

Molecular weight: 416.64

Ref: 04-A10934950AL-100

Vitamin D3-1α,25-dihydroxy (Calcitriol)

Controlled Product

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Color and Shape: Neat

Molecular weight: 416.64

Ref: 04-CA10934950

Calcitriol

Controlled Product

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Color and Shape: Neat

Molecular weight: 416.64

Ref: 86-MM0205.00

Calcitriol

CAS: 32222-06-3

Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM).

Formula: C₂₇H₄₄O₃

Purity: 98.81% - 99.64%

Color and Shape: Colorless Crystalline Solid Solid

Molecular weight: 416.64

Ref: TM-T6316

Calcitriol

Controlled Product

CAS: 32222-06-3

Formula: C₂₇H₄₄O₃

Color and Shape: White To Light Yellow

Molecular weight: 416.64

Ref: TR-C144500

1a,25-Dihydroxyvitamin D3

CAS: 32222-06-3

Calcitriol is a steroid hormone, vitamin D metabolite and agonist of vitamin D receptor (VDR), also known as calcitriol receptor. It regulates absorption of calcium from intestine, resorption of bone calcium and calcium excretion via kidneys. This compound also controls cell cycle, promotes cell differentiation, triggers apoptosis and acts as anti-inflammatory factor within the tumor microenvironment. It has anti-proliferative effects in malignant epithelial cells and in tumour-derived endothelial cells (TDEC). Also, it is a potent inhibitor of retinal neoangiogenesis in vitro.

Formula: C₂₇H₄₄O₃

Purity: Min. 98 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 416.32905

Ref: 3D-FC09794