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CAS 32222-06-3

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Calcitriol

Description:
Calcitriol, with the CAS number 32222-06-3, is the active form of vitamin D3, also known as 1,25-dihydroxyvitamin D3. It is a secosteroid hormone that plays a crucial role in calcium and phosphate metabolism in the body. Calcitriol is characterized by its ability to enhance intestinal absorption of calcium and phosphate, promoting bone health and mineralization. It is synthesized in the kidneys from its precursor, calcidiol, which is produced in the liver from vitamin D3. Calcitriol exerts its biological effects by binding to the vitamin D receptor (VDR), influencing gene expression and cellular functions. It is a fat-soluble compound, which means it is soluble in lipids but not in water, and it has a relatively low molecular weight. Due to its significant role in maintaining calcium homeostasis, calcitriol is often used therapeutically in conditions such as osteoporosis, rickets, and certain types of hypoparathyroidism. Its regulation is tightly controlled by various factors, including parathyroid hormone levels and serum calcium concentrations.
Formula:C27H44O3
InChI:InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1
InChI key:InChIKey=GMRQFYUYWCNGIN-NKMMMXOESA-N
SMILES:C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCC(C)(C)O)C)[H])[H]
Synonyms:
  • (1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • (1R,5Z)-5-[(2E)-2-[(1R,7aR)-1-(5-hydroxy-1,5-dimethyl-hexyl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylene-cyclohexane-1,3-diol
  • (1S,3R)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
  • (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
  • (1S,3R,5Z,7E,14xi)-9,10-secocholesta-5,7,10-triene-1,3,25-triol
  • (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trienetriol
  • (5Z,7E)-(1S,3R)-9,10-Secocholesta-5,7,10(19)-Triene-1,3,25-Triol
  • 1,25-Dihydroxycholecalciferol
  • 1,25-Dihydroxyvitamin D
  • 1,25-Dihydroxyvitamin D<sub>3</sub>
  • See more synonyms
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