CAS 32381-30-9

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-cysteinyl-, phenylmethyl ester, bimol. (1→1′)-disulfide

Description:

Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-cysteinyl-, phenylmethyl ester, bimol. (1→1′)-disulfide, with CAS number 32381-30-9, is a synthetic compound that features a complex structure incorporating amino acids and a disulfide bond. This compound is characterized by the presence of a glycine moiety and a cysteine residue, which is modified with a phenylmethyl ester and a protective group (1,1-dimethylethoxy) that enhances its stability and solubility. The disulfide linkage indicates that it exists as a dimer, which is significant for its biological activity, particularly in protein folding and stability. The compound is likely to exhibit properties typical of peptides, such as being soluble in polar solvents and having potential reactivity due to the thiol group in cysteine. Its unique structure may also confer specific interactions in biological systems, making it of interest in biochemical research and potential therapeutic applications. As with many synthetic peptides, careful handling and characterization are essential for understanding its behavior in various environments.

Formula: C₃₄H₄₆N₄O₁₀S₂

InChI: InChI=1S/C34H46N4O10S2/c1-33(2,3)47-31(43)37-25(29(41)35-17-27(39)45-19-23-13-9-7-10-14-23)21-49-50-22-26(38-32(44)48-34(4,5)6)30(42)36-18-28(40)46-20-24-15-11-8-12-16-24/h7-16,25-26H,17-22H2,1-6H3,(H,35,41)(H,36,42)(H,37,43)(H,38,44)/t25-,26-/m0/s1

InChI key: InChIKey=XWPSZYXJKVIUMV-UIOOFZCWSA-N

SMILES: [C@@H](NC(OC(C)(C)C)=O)(C(NCC(OCC1=CC=CC=C1)=O)=O)CSSC[C@H](NC(OC(C)(C)C)=O)C(NCC(OCC2=CC=CC=C2)=O)=O

Synonyms:

• Glycine, N,N′-(N,N′-dicarboxy-L-cystyl)di-, dibenzyl N,N′-di-tert-butyl ester
• Glycine, N-[(1,1-dimethylethoxy)carbonyl]-L-cysteinyl-, phenylmethyl ester, bimol. (1→1′)-disulfide

N,N'-(N,N'-Dicarboxy-L-cystyl)di-glycine Dibenzyl N,N'-Di-tert-butyl Ester (>90%)

Controlled Product

CAS: 32381-30-9

Applications N,N'-(N,N'-Dicarboxy-L-cystyl)di-glycine Dibenzyl N,N'-Di-tert-butyl Ester is an intermediate of Glutathione Ammonium Salt-d5 which is the isotope labelled analog of Glutathione. Glutathione may decrease the concentrations of inflammatory cytokines (IL-6, IL-18), neutrophils in lung tissue and increase the level of serum Ca2+ and be useful for the treatment of ANP. Glutathione production is regulated via distinct pathways in stressed and non-stressed cortical neurons.
References Misko, T., et al.: J. Biol. chem., 273, 15646 (1998), Nakamura, K., et al.: J. Biol. Chem., 276, 34402 (2001), Burdo, J., et al.: Brain Res. 1189, 12 (2008).

Formula: C₃₄H₄₆N₄O₁₀S₂

Purity: >90%

Color and Shape: Neat

Molecular weight: 734.88

Ref: TR-D430985