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CAS 3239-44-9

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Dexfenfluramine

Description:
Dexfenfluramine is a chemical compound that belongs to the class of phenethylamines and is primarily known for its use as an appetite suppressant. It is the dextrorotatory enantiomer of fenfluramine, which was previously prescribed for weight loss. The substance acts as a serotonin reuptake inhibitor, increasing serotonin levels in the brain, which can lead to reduced appetite. Dexfenfluramine is typically found in a white to off-white crystalline powder form and is soluble in water and alcohol. Its chemical structure includes a phenyl ring and an ethylamine side chain, contributing to its pharmacological properties. However, due to safety concerns, particularly regarding cardiovascular risks, dexfenfluramine was withdrawn from the market in many countries. Its use is now largely restricted, and it is classified as a controlled substance in some regions. Research continues into its mechanisms and potential therapeutic applications, but caution is advised due to its history of adverse effects.
Formula:C12H16F3N
InChI:InChI=1S/C12H16F3N/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15/h4-6,8-9,16H,3,7H2,1-2H3/t9-/m0/s1
InChI key:InChIKey=DBGIVFWFUFKIQN-VIFPVBQESA-N
SMILES:C([C@@H](NCC)C)C1=CC(C(F)(F)F)=CC=C1
Synonyms:
  • (αS)-N-Ethyl-α-methyl-3-(trifluoromethyl)benzeneethanamine
  • dexfenfluramine
  • Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-, (αS)-
  • d-Fenfluramine
  • N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
  • Benzeneethanamine, N-ethyl-α-methyl-3-(trifluoromethyl)-, (S)-
  • Phenethylamine, N-ethyl-α-methyl-m-(trifluoromethyl)-, (S)-
  • (2S)-N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine
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