CAS 32604-86-7

N-(4-{[4-(hydroxyamino)phenyl]sulfonyl}phenyl)acetamide

Description:

N-(4-{[4-(hydroxyamino)phenyl]sulfonyl}phenyl)acetamide, with the CAS number 32604-86-7, is a chemical compound characterized by its complex structure, which includes an acetamide group and a sulfonamide moiety. This compound features a hydroxyamino group, which contributes to its potential reactivity and biological activity. It is typically a solid at room temperature and may exhibit solubility in polar solvents due to the presence of functional groups capable of hydrogen bonding. The sulfonyl group enhances its chemical stability and can influence its interactions in biological systems. This compound may be of interest in medicinal chemistry, particularly for its potential applications in drug development, given its structural features that could interact with biological targets. Its properties, such as melting point, solubility, and reactivity, would depend on the specific conditions and the presence of other chemical entities. As with many organic compounds, safety and handling precautions should be observed due to potential toxicity or reactivity.

Formula: C₁₄H₁₄N₂O₄S

InChI: InChI=1/C14H14N2O4S/c1-10(17)15-11-2-6-13(7-3-11)21(19,20)14-8-4-12(16-18)5-9-14/h2-9,16,18H,1H3,(H,15,17)

InChI key: YUWDJHZQRAHBBW-UHFFFAOYSA-N

SMILES: CC(=Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)NO)O

4'-(N-Hydroxysulfanilyl)acetanilide

Controlled Product

CAS: 32604-86-7

Applications 4'-(N-Hydroxysulfanilyl)acetanilide is an intermediate in the synthesis of Aceyl Dapsone (A168435), a metabolite of Dapsone (D193250), an antibacterial used in the treatment of dermatitis herpetiformis.
References Shin, I., et al.: J. App. Pharmacol., 10, 193 (2002); Bhaiya, P., et al.: Toxicol. App. Pharmacol., 215, 158 (2006); Paixao, P., et al.: Eur. J. Pharm. Sci., 36, 544 (2009); Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950); Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009); Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009); Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)

Formula: C₁₄H₁₄N₂O₄S

Color and Shape: Neat

Molecular weight: 306.34

Ref: TR-H953820