CAS 326496-94-0

Formula: C17H30O4Si

InChI: InChI=1S/C17H30O4Si/c1-8-19-15(18)10-12-9-13(11-14-17(12,5)20-14)21-22(6,7)16(2,3)4/h10,13-14H,8-9,11H2,1-7H3/b12-10-/t13-,14+,17-/m1/s1

InChI key: WEBQGKTVYDUDHI-JURBKJLXSA-N

SMILES: CCOC(=O)/C=C\1/C[C@H](C[C@H]2[C@@]1(O2)C)O[Si](C)(C)C(C)(C)C

(2Z)-[(1R,4R,6S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-methyl-7-oxabicyclo[4.1.0]hept-2-ylidene]-acetic Acid Ethyl Ester

Controlled Product

CAS: 326496-94-0

Applications (2Z)-[(1R,4R,6S)-4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-methyl-7-oxabicyclo[4.1.0]hept-2-ylidene]-acetic Acid Ethyl Ester is an intermediate used in the synthesis of Calcitriol-d6 (C144502), which is the biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriatic.
References Myrtle, J.F., et al.: J. Biol. Chem., 245, 1190 (1970), Lawson, D.E.M., et al.: Nature, 230, 228 (1971), Norman, A.W., et al.: Science, 173, 51 (1971), Suda, T., et al.: Vitamins, 45, 175 (1972), Muindi, J.R., et al.: Clin. Pharmacol. Ther., 72, 648 (2002)

Formula: C₁₇H₃₀O₄Si

Color and Shape: Neat

Molecular weight: 326.5

Ref: TR-D474390