CAS 327036-89-5

4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Description:

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione is a heterocyclic compound characterized by a five-membered ring containing both sulfur and nitrogen atoms. This compound features a thiadiazolidine core, which is a derivative of thiadiazole, and is substituted with a benzyl group and a methyl group, contributing to its unique chemical properties. The presence of the dione functional groups indicates that it has two carbonyl (C=O) functionalities, which can participate in various chemical reactions, including nucleophilic additions and condensation reactions. The molecular structure suggests potential applications in medicinal chemistry, particularly in the development of pharmaceuticals, due to the presence of the thiadiazolidine framework, which is known for its biological activity. Additionally, the compound may exhibit interesting physical properties such as solubility in organic solvents and specific melting or boiling points, which are influenced by its molecular interactions. Overall, 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione represents a versatile structure with potential implications in various chemical and biological fields.

Formula: C₁₀H₁₀N₂O₂S

InChI: InChI=1/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3

InChI key: JDSJDASOXWCHPN-UHFFFAOYSA-N

SMILES: Cn1c(=O)n(Cc2ccccc2)c(=O)s1

Synonyms:

• 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-
• Tdzd-8

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purity: >98.0%(HPLC)

Color and Shape: White Solid Form

Molecular weight: 222.26

Ref: 3B-B4436

TDZD-8

CAS: 327036-89-5

TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purity: ≥95%

Molecular weight: 222.26

Ref: 54-BUP10327

TDZD-8

CAS: 327036-89-5

TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purity: 99.01% (Typical Value in Batch COA)

Color and Shape: Solid-Crystals

Molecular weight: 222.2636

Ref: 54-BISN0325

TDZD-8

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purity: ≥ 97.5%

Color and Shape: White to light-yellow to beige powder

Molecular weight: 222.26

Ref: 7W-GL4346

TDZD-8

CAS: 327036-89-5

TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

Formula: C₁₀H₁₀N₂O₂S

Purity: 97.13% - 99.61%

Color and Shape: Solid

Molecular weight: 222.26

Ref: TM-T6187

TDZD 8 - Bio-X ™

CAS: 327036-89-5

This product is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₁₀H₁₀N₂O₂S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 222.26 g/mol

Ref: 3D-BT300032

TDZD-8

CAS: 327036-89-5

TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purity: 98%

Molecular weight: 222.26

Ref: IN-DG94401

TDZD-8

CAS: 327036-89-5

M02610 - TDZD-8

Formula: C₁₀H₁₀N₂O₂S

Purity: 90%

Molecular weight: 222.26

Ref: 10-M02610

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

Controlled Product

CAS: 327036-89-5

Applications Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3ß ( IC50 =2nM). Binds to the active site of GSK-3ß. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).
References Martinez, A., et al.: J. Med. Chem., 45, 1292 (2002)

Formula: C₁₀H₁₀N₂O₂S

Color and Shape: Neat

Molecular weight: 222.26

Ref: TR-B285725

TDZD 8

CAS: 327036-89-5

TDZD 8 is a selective, non-ATP competitive inhibitor of the glycogen synthase kinase GSK3β. TDZD 8 inhibits GSK3β with IC50 of 2 μM and was reported to not significantly affect Cdk-1/cyclin B, casein kinase CK-II, protein kinase A and C (PKA, PKC) activities. TDZD 8 was also identified as an inhibitor of the main protease in coronaviruses. In an in vitro study, TDZD 8 was characterised as an aggregate-based inhibitor as the presence of Triton-X decreased the inhibitory potency to Mpro protease of the SARS-CoV-2 virus (IC50 without Triton-X: 2.15 μM).

Formula: C₁₀H₁₀N₂O₂S

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 222.26 g/mol

Ref: 3D-FB18327

4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

CAS: 327036-89-5

Formula: C₁₀H₁₀N₂O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 222.2636

Ref: IN-DA00C6HT