CAS 32795-47-4: Nomifensine maleate

Description: Nomifensine maleate is a pharmaceutical compound primarily recognized for its role as a dopamine reuptake inhibitor, which was used in the treatment of depression. It is classified as an antidepressant and is known for its ability to enhance mood by increasing the levels of dopamine in the synaptic cleft. The maleate salt form of nomifensine is utilized to improve its solubility and stability. The compound has a complex molecular structure, which contributes to its pharmacological effects. Nomifensine is characterized by its moderate lipophilicity, allowing it to cross the blood-brain barrier effectively. However, it is important to note that nomifensine has been associated with various side effects, including potential neurotoxicity, which led to its withdrawal from the market in many countries. Its chemical properties include a specific molecular weight and a defined melting point, which are critical for its formulation and therapeutic use. Overall, while nomifensine maleate has historical significance in psychopharmacology, its clinical application has been limited due to safety concerns.

Formula: C₁₆H₁₈N₂·C₄H₄O₄

InChI: InChI=1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key: InChIKey=GEOCVSMCLVIOEV-BTJKTKAUSA-N

SMILES: O=C(O)C=CC(=O)O.NC1=CC=CC2=C1CN(C)CC2C=3C=CC=CC3

Synonyms:

• (+-)-Nomifensine hydrogen maleate
• 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate
• 4-cyclohexyl-2-methyl-3,4-dihydro-1H-isoquinolin-8-amine
• 8-Amino-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinoline maleate (1:1)
• 8-Amino-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate
• 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (2Z)-2-butenedioate (1:1)
• 8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-, (Z)-2-butenedioate (1:1)
• Alival
• Alival (antidepressant)
• Ccris 1914
• Hoe 984
• Hostalival
• Merital
• Merital AM
• Neurolene
• Nomifensine maleate
• Nomifensine maleate [USAN]
• Nsc 289114
• Psicronizer
• Unii-76S8Cuh5Mr
• 8-Ammonio-1,2,3,4-tetrahydro-2-methyl-4-phenylisoquinolinium maleate

Nomifensine maleate salt

CAS: 32795-47-4

• Formula: C₂₀H₂₂N₂O₄
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 354.3997

Nomifensine maleate

CAS: 32795-47-4

• Purity: ≥98%
• Molecular weight: 354.4g/mol

Nomifensine maleate salt

CAS: 32795-47-4

• Formula: C₁₆H₁₈N₂·C₄H₄O₄
• Purity: ≥ 98.0%
• Color and Shape: Light yellow powder
• Molecular weight: 354.40

Nomifensine maleate

CAS: 32795-47-4

Nomifensine maleate (Nomifensine (maleate)) is a selective inhibitor of dopamine uptake. Nomifensine maleate is used …

• Formula: C₂₀H₂₂N₂O₄
• Purity: 98.46%
• Color and Shape: Solid
• Molecular weight: 354.4

Nomifensine Maleic Acid Salt

CAS: 32795-47-4

Applications A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure. …

• Formula: C₁₆H₁₈N₂·C₄H₄O₄
• Color and Shape: Neat
• Molecular weight: 354.40

(+/-)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate

CAS: 32795-47-4

(+/-)-2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-amine maleate is a bicyclic heterocycle that has been shown to interact with dopamine receptor …

• Purity: Min. 95%