CAS 328898-40-4
:Tildipirosin
Description:
Tildipirosin is a macrolide antibiotic primarily used in veterinary medicine, particularly for the treatment of respiratory diseases in livestock. It belongs to the class of compounds known as azalides, which are structurally related to erythromycin. Tildipirosin exhibits broad-spectrum antibacterial activity, particularly against Gram-positive bacteria and some Gram-negative organisms. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby preventing the growth and reproduction of bacteria. The substance is characterized by its high lipophilicity, which enhances its tissue distribution and allows for prolonged therapeutic effects. Tildipirosin is typically administered via injection and is known for its long half-life, which supports less frequent dosing regimens. Safety and efficacy studies have demonstrated its effectiveness in treating various infections, although its use is regulated to prevent the development of antibiotic resistance. As with all antibiotics, careful consideration of dosage and duration of treatment is essential to minimize potential side effects and ensure optimal outcomes in animal health.
Formula:C41H71N3O8
InChI:InChI=1S/C41H71N3O8/c1-8-35-32(26-44-20-13-10-14-21-44)23-27(2)15-16-33(45)28(3)24-31(17-22-43-18-11-9-12-19-43)40(29(4)34(46)25-36(47)51-35)52-41-39(49)37(42(6)7)38(48)30(5)50-41/h15-16,23,28-32,34-35,37-41,46,48-49H,8-14,17-22,24-26H2,1-7H3/b16-15+,27-23+/t28-,29+,30-,31+,32-,34-,35-,37+,38-,39-,40-,41+/m1/s1
InChI key:HNDXPZPJZGTJLJ-UEJFNEDBSA-N
SMILES:CC[C@@H]1[C@H](/C=C(/C=C/C(=O)[C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)O)C)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O)N(C)C)O)CCN3CCCCC3)C)\C)CN4CCCCC4
Synonyms:- 20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide
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Tildipirosin-d10 (>85%)
CAS:Controlled ProductApplications Labelled analogue of Tildipirosin, a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine.
References Rose, M. et al.: J. Vet. Pharmacol. Ther., (2012); Anderson, N.M. et al.: Antimicrob. Agents. Chemother., (2012);Formula:C41H61D10N3O8Purity:>85%Color and Shape:NeatMolecular weight:744.08Tildipirosin
CAS:Applications Tildipirosin is a novel 16-membered-ring macrolide used in veterinary medicine. Tildipirosin treats bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine (BRD Bovine Respiratory Disease).
References Rose, M. et al.: J. Vet. Pharmacol. Ther., (2012); Anderson, N.M. et al.: Antimicrob. Agents. Chemother., (2012);Formula:C41H71N3O8Color and Shape:NeatMolecular weight:734.02Tildipirosin
CAS:Tildipirosin, a veterinary antibiotic, is a 16-membered macrolide that blocks bacterial protein synthesis and biofilm formation.Formula:C41H71N3O8Purity:98.47%Color and Shape:White SolidMolecular weight:734.0177Tildipirosin
CAS:(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-(((2R,3R,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-16-ethyl-4-hydroxy-5,9,13-trimethyl-7-(2-(piperidin-1-yl)ethyl)-15-(piperidin-1-ylmethyl)oxacyclohexadeca-11,13-diene-2,10-dioneFormula:C41H71N3O8Purity:98%Molecular weight:734.0220-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide
CAS:20-Deoxo-23-deoxy-5-O-[3,6-dideoxy-3-(dimethylamino)-beta-D-glucopyranosyl]-20,23-di-1-piperidinyltylonolide is an antimicrobial agent that belongs to the group of chemotherapeutic agents. It is a fluorinated analog of tilmicosin. The low dose group was treated with this drug for five days, and the high dose group received 20 times the amount of drug. Fluorescence spectrometry showed that there was no significant difference in the fluorescence intensity between these two groups after 24 hours. This drug has been shown to have pharmacokinetic properties in rats and mice, but further optimization may be required to improve its process.Formula:C41H71N3O8Purity:Min. 95%Color and Shape:Off-White PowderMolecular weight:734.02 g/mol
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