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CAS 329-15-7

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4-(Trifluoromethyl)benzoyl chloride

Description:
4-(Trifluoromethyl)benzoyl chloride, with the CAS number 329-15-7, is an aromatic acyl chloride characterized by the presence of a trifluoromethyl group attached to the para position of a benzoyl chloride moiety. This compound is typically a colorless to pale yellow liquid with a pungent odor, indicative of its reactivity. It is known for its strong electrophilic nature due to the presence of the acyl chloride functional group, making it a useful intermediate in organic synthesis, particularly in the preparation of various fluorinated compounds. The trifluoromethyl group enhances the lipophilicity and metabolic stability of derivatives formed from this compound. Additionally, 4-(Trifluoromethyl)benzoyl chloride is sensitive to moisture and can hydrolyze to form the corresponding carboxylic acid, which can be a consideration in handling and storage. Safety precautions are essential when working with this substance, as it can be corrosive and harmful upon contact with skin or inhalation.
Formula:C8H4ClF3O
InChI:InChI=1S/C8H4ClF3O/c9-7(13)5-1-3-6(4-2-5)8(10,11)12/h1-4H
InChI key:InChIKey=OXZYBOLWRXENKT-UHFFFAOYSA-N
SMILES:C(F)(F)(F)C1=CC=C(C(Cl)=O)C=C1
Synonyms:
  • 4-(Trifluoromethyl)-1-benzenecarbonyl chloride
  • 4-(Trifluoromethyl)benzoic acid chloride
  • 4-Trifluoromethylphenylcarbonyl chloride
  • Benzoyl chloride, 4-(trifluoromethyl)-
  • Nsc 88292
  • alpha,alpha,alpha-Trifluoro-o-toluoyl chloride
  • alpha,alpha,alpha-Trifluoro-p-toluoyl chloride
  • p-(Trifluoromethyl)benzoyl chloride
  • p-Toluoyl chloride, alpha,alpha,alpha-trifluoro-
  • p-Toluoyl chloride, α,α,α-trifluoro-
  • See more synonyms
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