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CAS 329-98-6

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Phenylmethylsulfonyl fluoride

Description:
Phenylmethylsulfonyl fluoride (PMSF) is an organic compound characterized by its sulfonyl fluoride functional group, which contributes to its reactivity. It is typically a white to off-white crystalline solid at room temperature and is soluble in organic solvents such as acetone and ethanol, but has limited solubility in water. PMSF is primarily used as a serine protease inhibitor in biochemical research, making it valuable in the study of enzyme kinetics and protein purification. Its mechanism of action involves the formation of a covalent bond with the active site serine residue of enzymes, thereby inhibiting their activity. Additionally, PMSF is sensitive to moisture and should be stored in a dry environment to maintain its stability. Safety precautions are necessary when handling this compound, as it can be irritating to the skin, eyes, and respiratory system. Overall, PMSF is an important reagent in molecular biology and biochemistry, particularly in studies involving proteolytic enzymes.
Formula:C7H7FO2S
InChI:InChI=1/C7H7FO2S/c1-6-4-2-3-5-7(6)11(8,9)10/h2-5H,1H3
InChI key:InChIKey=YBYRMVIVWMBXKQ-UHFFFAOYSA-N
SMILES:C(S(F)(=O)=O)C1=CC=CC=C1
Synonyms:
  • .alpha.-Toluenesulfonyl fluoride
  • Benzenemethanesulfonyl Fluoride
  • Fluorure de phénylméthanesulfonyle
  • Phenylmethanesulfonyl fluoride
  • Phenylmethansulfonylfluorid
  • 2-Methylbenzenesulfonyl Fluoride
  • Pmsf
  • Phenylmethylsulfonyl fluoride
  • Benzylsulfonyl fluoride
  • Fluorure d'α-toluenesulfonyle
  • See more synonyms
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