CAS 32986-56-4: Tobramycin

Description: Tobramycin is an aminoglycoside antibiotic primarily used to treat infections caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is effective against a range of bacterial infections, especially in patients with cystic fibrosis or those with compromised immune systems. The substance is characterized by its ability to inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, leading to misreading of mRNA and ultimately cell death. Tobramycin is typically administered via inhalation, injection, or topical application, depending on the infection's location and severity. It is known for its relatively low toxicity compared to other aminoglycosides, although it can still cause nephrotoxicity and ototoxicity, necessitating careful monitoring of kidney function and hearing during treatment. The chemical structure of tobramycin includes multiple hydroxyl and amino groups, contributing to its solubility and biological activity. As with all antibiotics, the emergence of resistance is a concern, making appropriate use and adherence to prescribed regimens essential for maintaining its efficacy.

Formula: C₁₈H₃₇N₅O₉

InChI: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChI key: InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N

SMILES: OCC1OC(OC2C(O)C(OC3OC(CN)C(O)CC3N)C(N)CC2N)C(O)C(N)C1O

Synonyms:

• (1S,2S,3R,4S,6R)-4,6-diamino-3-[(2,6-diamino-2,3,6-trideoxy-alpha-D-ribo-hexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-alpha-D-glucopyranoside
• 3'-Deoxykanamycin B
• 4-Amino-2-[4,6-Diamino-3-[[2-Amino-5-(Aminomethyl)-4-Hydroxy-Cyclohexyl]Methyl]-2-Hydroxy-Cyclohexoxy]-6-(Hydroxymethyl)Tetrahydropyran-3,5-Diol
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</span>-ribo-hexopyranosyl-(1→4)]-2-deoxy-
• D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino- 2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-
• Deoxykanamycin B
• Nebramycin 6
• Nebramycin VI
• Nebramycin factor 6
• Nf 6
• Nsc 180514
• O-3-Amino-3-deoxy-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-<smallcap>D</smallcap>-ribo-hexopyranosyl-(1→4)]-2-deoxy-<smallcap>D</span>-streptamine
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxystreptamine
• O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→4)]-2-deoxy-D-streptamine
• Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)-O-[2,6-diamino-2,3,6-trideoxy-α-D-ribo-hexopyranosyl-(1→6)]-2-deoxy-, D-
• Tobi Podhaler
• Tobracin
• Tobradistin
• Tobralex
• Tobramax
• Tobramaxin
• Tobramicin
• Tobramicina
• Tobramycetin
• Tobramycin Base
• Tobramycin, Free Base
• Tobramycine
• Tobrex
• Tobrin
• Vantobra
• Tobramycin

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Purity: >94.0%(T)
• Color and Shape: White to Orange to Green powder to crystal
• Molecular weight: 467.52

Tobramycin, 900μg/mg

CAS: 32986-56-4

Primarily targets Gram-negative bacteria This Thermo Scientific Chemicals brand product was originally part of the …

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: White to pale cream, Powder
• Molecular weight: 467.52

Tobramycin for identification CRS

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: White. Powder.
• Molecular weight: 467.5145

Tobramycin CRS

CAS: 32986-56-4

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: White Solid
• Molecular weight: 467.5145

Second International Standard for Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Molecular weight: 467.5145

Tobramycin

CAS: 32986-56-4

Aminoglycoside antibiotics

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: White Off-White Powder
• Molecular weight: 467.25913

Tobramycin

CAS: 32986-56-4

Tobramycin (NSC-180514) is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius.

• Formula: C₁₈H₃₇N₅O₉
• Purity: 99.21% - 99.87%
• Color and Shape: White Solid
• Molecular weight: 467.51

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Purity: 95%
• Color and Shape: Solid
• Molecular weight: 467.5145

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Purity: >97% by area (tlc) (Typical Value in Batch COA)
• Color and Shape: white powder
• Molecular weight: 467.51g/mol

Tobramycin, EP grade

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Purity: ≤ 0.5%
• Color and Shape: White to off-white powder
• Molecular weight: 467.5

Tobramycin

CAS: 32986-56-4

• Purity: ≥98%
• Molecular weight: 467.51g/mol

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Purity: ≥ 900μg/mg (anhydrous basis)
• Color and Shape: White or almost white powder
• Molecular weight: 467.5

Tobramycin

CAS: 32986-56-4

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: Neat
• Molecular weight: 467.51

Tobramycin, 97%

CAS: 32986-56-4

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₁₈H₃₇N₅O₉
• Purity: 97%
• Color and Shape: White to light yellow, Powder
• Molecular weight: 467.52

Tobramycin

CAS: 32986-56-4

Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex produced by …

• Formula: C₁₈H₃₇N₅O₉
• Color and Shape: White To Off-White
• Molecular weight: 467.51

Tobramycin-D, 18O Acetic Acid Salt

CAS: 32986-56-4

• Formula: C₁₈H₃₆DN₅O₈O·(xCH₃COOH)
• Color and Shape: Off White Solid
• Molecular weight: 470.52 +(x60.05)

Tobramycin

CAS: 32986-56-4

• Molecular weight: 467.519989013672

Tobramycin Sulphate Salt

CAS: 32986-56-449842-07-1

• Formula: C₁₈H₃₇N₅O₉•x(H₂O₄S)
• Color and Shape: Neat
• Molecular weight: 467.51+x(98.08)

Tobramycin Deuterated

CAS: 32986-56-4

Stability Hygroscopic Applications Single factor antibiotic comprising about 10% of nebramycin, the aminoglycosidic antibiotic complex …

• Formula: C₁₈H₃₇N₅O₉forundeuterated
• Color and Shape: Dark Yellow
• Molecular weight: 467.51