CAS 33069-62-4
:Paclitaxel
Description:
Paclitaxel, with the CAS number 33069-62-4, is a complex natural product and a chemotherapeutic agent primarily used in the treatment of various cancers, including ovarian, breast, and lung cancer. It is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is classified as a taxane. Paclitaxel functions by stabilizing microtubules and preventing their depolymerization, which disrupts the normal process of cell division, ultimately leading to apoptosis in cancer cells. The compound is characterized by its unique structure, which includes a taxane ring system and several functional groups that contribute to its biological activity. Paclitaxel is typically administered intravenously and has a relatively low solubility in water, often requiring formulation with solvents like Cremophor EL for clinical use. Its side effects can include neutropenia, hypersensitivity reactions, and peripheral neuropathy. Due to its efficacy and mechanism of action, paclitaxel remains a cornerstone in oncological therapies, although its use is often accompanied by careful monitoring and supportive care.
Formula:C47H51NO14
InChI:InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChI key:InChIKey=RCINICONZNJXQF-MZXODVADSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]
Synonyms:- 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
- 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
- 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
- Abi 007
- Abraxane
- Anzatax
- Apealea
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
- Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
- Bms 181339-01
- Capxol
- Coroflex Please
- Cremophor-free paclitaxel
- Cyclopax
- Cynviloq
- Cypher select
- Dhp 107
- Ebetaxel
- EmPAC
- EndoTAG 1
- Genaxol
- Genetaxyl
- Genexol
- Genexol-PM
- Ig 001
- Ig 002
- Infinnium
- Intaxel
- Lep-Etu
- Liposome-entrapped paclitaxel easy-to-use
- Mbt 0206
- Mitotax
- Nab-paclitaxel
- Nanotax
- Nanoxel
- Nk 105
- Nsc 125973
- OncoGel
- Onxal
- Oraxol
- Pacitaxel
- Pacliex
- Padexol
- Paxene
- Pazenir
- Plaxicel
- Qw 8184
- Sindaxel
- TAXUS Express
- TAXUS stent
- Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
- TaxAlbin
- Taxal
- Taxol
- Taxol A
- Taxus
- Taxus Liberte
- Tocosol Paclitaxel
- See more synonyms
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Paclitaxel
CAS:Formula:C47H51NO14Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:853.92Paclitaxel, 99.5+%
CAS:Paclitaxel, 33069-62-4, also known as Taxol, is an anticancer agent which acts through disruption of microtubule growth. Learn more at Thermo Fisher Scientific.Formula:C47H51NO14Purity:99.5+%Color and Shape:White to cream, Crystalline powder or granularMolecular weight:853.92PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS
CAS:PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRSFormula:C47H51NO14Molecular weight:853.9061PACLITAXEL CRS
CAS:PACLITAXEL CRSFormula:C47H51NO14Color and Shape:Crystalline Powder. White. Powder.Molecular weight:853.9061PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS
CAS:PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRSPACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS
CAS:PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRSFormula:C47H51NO14Molecular weight:853.9061Paclitaxel
CAS:Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoiFormula:C47H51NO14Color and Shape:White Off-White PowderMolecular weight:853.33096Paclitaxel
CAS:Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.
Formula:C47H51NO14Purity:98% - 99.92%Color and Shape:White PowderMolecular weight:853.91Paclitaxel
CAS:Formula:C47H51NO14Purity:97.0 - 102.0 % (anhydrous basis)Color and Shape:White powderMolecular weight:853.91Paclitaxel (Docetaxel EP Impurity F)
CAS:Formula:C47H51NO14Color and Shape:White To Off-White SolidMolecular weight:853.92Paclitaxel
CAS:Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats.Formula:C47H51NO14Purity:95%~99%Molecular weight:853.918Paclitaxel, Taxus brevifolia
CAS:M02242 - Paclitaxel, Taxus brevifolia
Formula:C47H51NO14Purity:>98%Color and Shape:Solid, PowderMolecular weight:853.918Paclitaxel (1mg×5)
CAS:Formula:C47H51NO14Color and Shape:White to Almost white powder to crystalMolecular weight:853.92Paclitaxel from Taxus Mairei
CAS:Paclitaxel from Taxus MaireiFormula:C47H51NO14Purity:By hplc: consistent with structure (Typical Value in Batch COA)Color and Shape: solidMolecular weight:853.91g/molTaxol
CAS:Oxygen-heterocyclic compoundFormula:C47H51NO14Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:853.92Paclitaxel-13C6
CAS:Controlled ProductApplications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),Formula:C4113C6H51NO14Color and Shape:NeatMolecular weight:859.86Paclitaxel
CAS:Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),Formula:C47H51NO14Color and Shape:Off-WhiteMolecular weight:853.91
