CAS 33069-62-4: Paclitaxel

Description: Paclitaxel, with the CAS number 33069-62-4, is a complex natural product and a chemotherapeutic agent primarily used in the treatment of various cancers, including ovarian, breast, and lung cancer. It is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is classified as a taxane. Paclitaxel functions by stabilizing microtubules and preventing their depolymerization, which disrupts the normal process of cell division, ultimately leading to apoptosis in cancer cells. The compound is characterized by its unique structure, which includes a taxane ring system and several functional groups that contribute to its biological activity. Paclitaxel is typically administered intravenously and has a relatively low solubility in water, often requiring formulation with solvents like Cremophor EL for clinical use. Its side effects can include neutropenia, hypersensitivity reactions, and peripheral neuropathy. Due to its efficacy and mechanism of action, paclitaxel remains a cornerstone in oncological therapies, although its use is often accompanied by careful monitoring and supportive care.

Formula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O=C(OC1C2C3(OC(=O)C)COC3CC(O)C2(C(=O)C(OC(=O)C)C4=C(C)C(OC(=O)C(O)C(NC(=O)C=5C=CC=CC5)C=6C=CC=CC6)CC1(O)C4(C)C)C)C=7C=CC=CC7

Synonyms:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel
• Yewtaxan

Paclitaxel

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 853.92

Paclitaxel, 99.5+%

CAS: 33069-62-4

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. …

• Formula: C₄₇H₅₁NO₁₄
• Purity: 99.5+%
• Color and Shape: White to cream, Crystalline powder or granular
• Molecular weight: 853.92

Paclitaxel, Taxus brevifolia

CAS: 33069-62-4

M02242 - Paclitaxel, Taxus brevifolia

• Formula: C₄₇H₅₁NO₁₄
• Purity: >98%
• Color and Shape: Solid, Powder
• Molecular weight: 853.9180297851562

Paclitaxel semi-synthetic for system suitability CRS

CAS: 33069-62-4

Paclitaxel natural for peak identification CRS

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Molecular weight: 853.9061

Paclitaxel semi-synthetic for peak identification CRS

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Molecular weight: 853.9061

Paclitaxel CRS

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: Crystalline Powder. White. Powder.
• Molecular weight: 853.9061

Paclitaxel

CAS: 33069-62-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: White Off-White Powder
• Molecular weight: 853.33096

7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: Solid
• Molecular weight: 853.9061

Paclitaxel

CAS: 33069-62-4

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.

• Formula: C₄₇H₅₁NO₁₄
• Purity: 98% - 99.92%
• Color and Shape: White Powder
• Molecular weight: 853.91

Paclitaxel (Docetaxel EP Impurity F)

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: White To Off-White Solid
• Molecular weight: 853.92

Paclitaxel

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: Neat
• Molecular weight: 853.91

Paclitaxel, 99+%

CAS: 33069-62-4

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Formula: C₄₇H₅₁NO₁₄
• Purity: 99+%
• Color and Shape: White, Powder
• Molecular weight: 853.92

Paclitaxel

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: Neat
• Molecular weight: 853.91

Paclitaxel

CAS: 33069-62-4

Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, …

• Formula: C₄₇H₅₁NO₁₄
• Purity: 95%~99%
• Molecular weight: 853.918

Paclitaxel (1mg×5)

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 853.92

Paclitaxel from Taxus Mairei

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Purity: By hplc: consistent with structure (Typical Value in Batch COA)
• Color and Shape: solid
• Molecular weight: 853.91g/mol

Paclitaxel

CAS: 33069-62-4

• Formula: C₄₇H₅₁NO₁₄
• Purity: 97.0 - 102.0 % (anhydrous basis)
• Color and Shape: White powder
• Molecular weight: 853.91

Taxol

CAS: 33069-62-4

Oxygen-heterocyclic compound

• Formula: C₄₇H₅₁NO₁₄
• Purity: ≥ 95.0 % (HPLC)
• Color and Shape: Powder
• Molecular weight: 853.92

Paclitaxel-13C6

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in …

• Formula: C₄₁₁₃C₆H₅₁NO₁₄
• Color and Shape: Neat
• Molecular weight: 859.86