CAS 33069-62-4

Paclitaxel

Description:

Paclitaxel, with the CAS number 33069-62-4, is a complex natural product and a chemotherapeutic agent primarily used in the treatment of various cancers, including ovarian, breast, and lung cancer. It is derived from the bark of the Pacific yew tree (Taxus brevifolia) and is classified as a taxane. Paclitaxel functions by stabilizing microtubules and preventing their depolymerization, which disrupts the normal process of cell division, ultimately leading to apoptosis in cancer cells. The compound is characterized by its unique structure, which includes a taxane ring system and several functional groups that contribute to its biological activity. Paclitaxel is typically administered intravenously and has a relatively low solubility in water, often requiring formulation with solvents like Cremophor EL for clinical use. Its side effects can include neutropenia, hypersensitivity reactions, and peripheral neuropathy. Due to its efficacy and mechanism of action, paclitaxel remains a cornerstone in oncological therapies, although its use is often accompanied by careful monitoring and supportive care.

Formula: C₄₇H₅₁NO₁₄

InChI: InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1

InChI key: InChIKey=RCINICONZNJXQF-MZXODVADSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Synonyms:

• 5β,20-Epoxy-1,2a,4,7β,10β,13α-hexahydroxy-tax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7,11-Methano-5H-Cyclodeca[3,4]Benz[1,2-B]Oxete Benzenepropanoic Acid Deriv.
• Abi 007
• Abraxane
• Anzatax
• Apealea
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
• Bms 181339-01
• Capxol
• Coroflex Please
• Cremophor-free paclitaxel
• Cyclopax
• Cynviloq
• Cypher select
• Dhp 107
• Ebetaxel
• EmPAC
• EndoTAG 1
• Genaxol
• Genetaxyl
• Genexol
• Genexol-PM
• Ig 001
• Ig 002
• Infinnium
• Intaxel
• Lep-Etu
• Liposome-entrapped paclitaxel easy-to-use
• Mbt 0206
• Mitotax
• Nab-paclitaxel
• Nanotax
• Nanoxel
• Nk 105
• Nsc 125973
• OncoGel
• Onxal
• Oraxol
• Pacitaxel
• Pacliex
• Padexol
• Paxene
• Pazenir
• Plaxicel
• Qw 8184
• Sindaxel
• TAXUS Express
• TAXUS stent
• Tax-11-en-9-one, 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxy-, 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
• TaxAlbin
• Taxal
• Taxol
• Taxol A
• Taxus
• Taxus Liberte
• Tocosol Paclitaxel

Paclitaxel

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 853.92

Ref: 3B-P1632

Paclitaxel, 99.5+%

CAS: 33069-62-4

Paclitaxel, 33069-62-4, also known as Taxol, is an anticancer agent which acts through disruption of microtubule growth. Learn more at Thermo Fisher Scientific.

Formula: C₄₇H₅₁NO₁₄

Purity: 99.5+%

Color and Shape: White to cream, Crystalline powder or granular

Molecular weight: 853.92

Ref: 02-J62734

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL NATURAL FOR PEAK IDENTIFICATION CRS

Formula: C₄₇H₅₁NO₁₄

Molecular weight: 853.9061

Ref: 41-Y0000700

PACLITAXEL CRS

CAS: 33069-62-4

PACLITAXEL CRS

Formula: C₄₇H₅₁NO₁₄

Color and Shape: Crystalline Powder. White. Powder.

Molecular weight: 853.9061

Ref: 41-Y0000698

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR SYSTEM SUITABILITY CRS

Ref: 41-Y0000739

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

CAS: 33069-62-4

PACLITAXEL SEMI-SYNTHETIC FOR PEAK IDENTIFICATION CRS

Formula: C₄₇H₅₁NO₁₄

Molecular weight: 853.9061

Ref: 41-Y0000719

Paclitaxel

CAS: 33069-62-4

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₇H₅₁NO₁₄

Color and Shape: White Off-White Powder

Molecular weight: 853.33096

Ref: 45-1491332

Paclitaxel

CAS: 33069-62-4

Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer.

Formula: C₄₇H₅₁NO₁₄

Purity: 98% - 99.92%

Color and Shape: White Powder

Molecular weight: 853.91

Ref: TM-T0968

Paclitaxel

CAS: 33069-62-4

Paclitaxel

Purity: ≥98%

Molecular weight: 853.91g/mol

Ref: 54-BUP20834

Paclitaxel

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Purity: 97.0 - 102.0 % (anhydrous basis)

Color and Shape: White powder

Molecular weight: 853.91

Ref: 7W-GA4564

Paclitaxel (Docetaxel EP Impurity F)

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Color and Shape: White To Off-White Solid

Molecular weight: 853.92

Ref: 4Z-P-283

Paclitaxel

CAS: 33069-62-4

Paclitaxel is a potent anticancer medication which can promote microtubule (MT) assembly, inhibits MT depolymerization, and changes MT dynamics required for mitosis and cell proliferation. Paclitaxel can induce ototoxicity in rats.

Formula: C₄₇H₅₁NO₁₄

Purity: 95%~99%

Molecular weight: 853.918

Ref: BP-BP1055

Paclitaxel, Taxus brevifolia

CAS: 33069-62-4

M02242 - Paclitaxel, Taxus brevifolia

Formula: C₄₇H₅₁NO₁₄

Purity: >98%

Color and Shape: Solid, Powder

Molecular weight: 853.918

Ref: 10-M02242

Paclitaxel

Controlled Product

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Color and Shape: Off-White

Molecular weight: 853.91

Ref: 04-C15839000

Paclitaxel

Controlled Product

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Color and Shape: Off-White

Molecular weight: 853.91

Ref: 86-MM1489.00

Paclitaxel (1mg×5)

CAS: 33069-62-4

Formula: C₄₇H₅₁NO₁₄

Color and Shape: White to Almost white powder to crystal

Molecular weight: 853.92

Ref: 3B-P3207

Paclitaxel from Taxus Mairei

CAS: 33069-62-4

Paclitaxel from Taxus Mairei

Formula: C₄₇H₅₁NO₁₄

Purity: By hplc: consistent with structure (Typical Value in Batch COA)

Color and Shape: solid

Molecular weight: 853.91g/mol

Ref: 54-BIP1002

Taxol

CAS: 33069-62-4

Oxygen-heterocyclic compound

Formula: C₄₇H₅₁NO₁₄

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 853.92

Ref: 5G-89806

Paclitaxel-13C6

Controlled Product

CAS: 33069-62-4

Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₁₁₃C₆H₅₁NO₁₄

Color and Shape: Neat

Molecular weight: 859.86

Ref: TR-P132504

Paclitaxel

CAS: 33069-62-4

Applications An antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),

Formula: C₄₇H₅₁NO₁₄

Color and Shape: Off-White

Molecular weight: 853.91

Ref: TR-P132500