CAS 332-80-9

1-Methyl-L-histidine

Description:

1-Methyl-L-histidine, with the CAS number 332-80-9, is a naturally occurring amino acid derivative of histidine. It is characterized by the presence of a methyl group attached to the nitrogen atom of the imidazole side chain of histidine. This modification can influence its biochemical properties and interactions. 1-Methyl-L-histidine is known to play a role in muscle metabolism and is often studied in the context of protein synthesis and muscle function. It is soluble in water and exhibits polar characteristics due to its amino and carboxyl functional groups. The compound is typically found in various biological systems and can be involved in metabolic pathways. Its presence in muscle tissue has been linked to the regulation of muscle protein turnover. As a research compound, it may also serve as a biomarker for certain physiological conditions. Overall, 1-Methyl-L-histidine is significant in both biochemical research and potential clinical applications related to muscle health and metabolism.

Formula: C₇H₁₁N₃O₂

InChI: InChI=1S/C7H11N3O2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6H,2,8H2,1H3,(H,11,12)/t6-/m0/s1

InChI key: InChIKey=BRMWTNUJHUMWMS-LURJTMIESA-N

SMILES: C([C@@H](C(O)=O)N)C=1N=CN(C)C1

Synonyms:

• (2S)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid
• (S)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid
• 1-Methyl-<span class="text-smallcaps">L</span>-histidine
• 1-Methylhistidine
• 1-N-Methyl-<span class="text-smallcaps">L</span>-histidine
• 1-methyl-L-histidine
• <span class="text-smallcaps">L</span>-Histidine, 1-methyl-
• Histidine, 1-methyl-, <span class="text-smallcaps">L</span>-
• N₁-Methyl-<span class="text-smallcaps">L</span>-histidine
• NSC 524367
• π-N-Methyl-<span class="text-smallcaps">L</span>-histidine
• τ-Methylhistidine
• L-Histidine, 1-methyl-
• 1-N-Methyl-L-histidine

H-His(1-Me)-OH

CAS: 332-80-9

(S)-2-Amino-3-(1-methyl-1H-imidazol-4-yl)propanoic acid

Formula: C₇H₁₁N₃O₂

Purity: 97%

Molecular weight: 169.18

Ref: IN-DG10065

1-Methyl-L-histidine

CAS: 332-80-9

Formula: C₇H₁₁N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 169.1811

Ref: IN-DA0032T9

1-Methyl-L-histidine

CAS: 332-80-9

Molecular weight: 169.18

Ref: 7W-GM5450

1-Methyl-L-histidine

CAS: 332-80-9

1-Methyl-L-histidine

Formula: C₇H₁₁N₃O₂

Purity: ≥98%

Molecular weight: 169.18

Ref: 54-BUP06200

H-His(1-Me)-OH H-His(t-Me)-OH

CAS: 332-80-9

H-His(1-Me)-OH H-His(t-Me)-OH

Formula: C₇H₁₁N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 169.18114

Ref: 54-OR36342

1-Methyl-L-histidine

Controlled Product

CAS: 332-80-9

Applications The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.
References Berna, M., et al.: Anal. Chem., 79, 4199 (2007), Pritt, M., et al.: Toxicol. Sci., 103, 382 (2008), Tonomura, Y., et al.: Toxicology, 266, 48 (2009),

Formula: C₇H₁₁N₃O₂

Color and Shape: Neat

Molecular weight: 169.18

Ref: TR-M312050

1-Methyl-L-histidine

CAS: 332-80-9

1-Methyl-L-histidine is an amino acid that is a component of protein. It is a potential biomarker for detecting inflammation and may be used as an indicator of renal function. 1-Methyl-L-histidine has been shown to be higher in the serum of diabetic patients than in healthy individuals, although it is not yet known if this difference is due to the disease or other factors. The chemical structure of 1-methyl-L-histidine consists of one methyl group attached to histidine. 1-Methyl-L-histidine fluoresces at a wavelength of 364 nm when excited with ultraviolet light at 315 nm. The fluorescence emission spectrum can be used as a measure for kinetic data on protein synthesis in vivo, such as the rate at which tryptophan is incorporated into proteins.

Formula: C₇H₁₁N₃O₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 169.18 g/mol

Ref: 3D-FM25864

1-Methyl-L-histidine

CAS: 332-80-9

1-Methyl-L-histidine (3-(1-Methylimidazol-4-yl)-L-alanine) is a natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.

Formula: C₇H₁₁N₃O₂

Purity: 99.79% - 99.83%

Color and Shape: Solid

Molecular weight: 169.18

Ref: TM-T4934

H-His(1-Me)-OH

CAS: 332-80-9

M02991 - H-His(1-Me)-OH

Formula: C₇H₁₁N₃O₂

Purity: 98%

Color and Shape: Solid, Yellowish Powder

Molecular weight: 169.184

Ref: 10-M02991

H-His(1-Me)-OH

CAS: 332-80-9

Bachem ID: 4041045.

Formula: C₇H₁₁N₃O₂

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 169.18

Ref: 01-4041045