CAS 33342-05-1

Gliquidone

Description:

Gliquidone is an oral hypoglycemic agent belonging to the class of sulfonylureas, primarily used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from the pancreatic beta cells, thereby lowering blood glucose levels. Gliquidone is characterized by its chemical structure, which includes a sulfonylurea moiety, contributing to its pharmacological activity. The substance is typically administered in tablet form and is known for its moderate efficacy in glycemic control. Its pharmacokinetics involve absorption in the gastrointestinal tract, with peak plasma concentrations occurring within a few hours post-administration. Gliquidone is metabolized in the liver, and its metabolites are excreted primarily through the urine. Common side effects may include hypoglycemia, gastrointestinal disturbances, and allergic reactions. As with other sulfonylureas, it is essential for patients to monitor their blood glucose levels regularly and maintain a balanced diet and exercise regimen to optimize treatment outcomes. Caution is advised in patients with renal or hepatic impairment, as these conditions may affect the drug's metabolism and clearance.

Formula: C₂₇H₃₃N₃O₆S

InChI: InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33)

InChI key: InChIKey=LLJFMFZYVVLQKT-UHFFFAOYSA-N

SMILES: CC1(C)C=2C(C(=O)N(CCC3=CC=C(S(NC(NC4CCCCC4)=O)(=O)=O)C=C3)C1=O)=CC(OC)=CC2

Synonyms:

• 1-Cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzenesulfonyl]urea
• 1-Cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
• 1-Cyclohexyl-3-[[p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinoyl)ethyl]phenyl]sulfonyl]urea
• Ar 3-Ardf 26
• Ar-Df 26
• Ardf 26Se
• Beglynor
• Glichidon
• Gliquidona
• Gliquidone
• Glurenorm
• N-[(Cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]benzenesulfonamide
• TangShenPing
• TangShiPing
• Zinc 01482077
• Zinc 1482077

Gliquidone

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 527.64

Ref: 3B-G0332

Gliquidone

CAS: 33342-05-1

Gliquidone (AR-DF 26) is a potent, second-generation sulfonylurea with antihyperglycemic activity.

Formula: C₂₇H₃₃N₃O₆S

Purity: 98.92% - 99.93%

Color and Shape: Solid

Molecular weight: 527.63

Ref: TM-T0371

1-cyclohexyl-3-({4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene}sulfonyl)urea

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Purity: 99%

Color and Shape: Solid

Molecular weight: 527.6324

Ref: IN-DA0034YT

Gliquidone

CAS: 33342-05-1

Gliquidone

Formula: C₂₇H₃₃N₃O₆S

Purity: ≥98%

Molecular weight: 527.63

Ref: 54-BUP14986

Gliquidone

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 527.64

Ref: 4Z-G-050001

Gliquidone

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Purity: ≥ 98.0%

Color and Shape: White to off-white or pale yellow crystalline powder

Molecular weight: 527.63

Ref: 7W-GP4220

N-(Cyclohexylcarbamoyl)-4-(2-(7-Methoxy-4,4-Dimethyl-1,3-Dioxo-3,4-Dihydroisoquinolin-2(1H)-Yl)Ethyl)Benzenesulfonamide

CAS: 33342-05-1

N-(Cyclohexylcarbamoyl)-4-(2-(7-Methoxy-4,4-Dimethyl-1,3-Dioxo-3,4-Dihydroisoquinolin-2(1H)-Yl)Ethyl)Benzenesulfonamide

Formula: C₂₇H₃₃N₃O₆S

Purity: 99%

Molecular weight: 527.63

Ref: 54-OR1029252

Gliquidone-d6

CAS: 33342-05-1

Formula: C₂₇H₂₇D₆N₃O₆S

Color and Shape: White To Off-White Solid

Molecular weight: 533.67

Ref: 4Z-G-050002

Gliquidone

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Color and Shape: Neat

Molecular weight: 527.63

Ref: 86-MM3094.00

Gliquidone

Controlled Product

CAS: 33342-05-1

Applications Gliquidone is an anti diabetic agent used in the treatment of hypoglycemia which leads to an increased risk in diabetic cardiovascular disease. Also used in the treatment diabetic nephropathy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tan, Z. et al.: Chinese Med. J., 127, 1298 (2014); Ke, J, et al.: J. Endocrinol., 220, 129 (2014);

Formula: C₂₇H₃₃N₃O₆S

Color and Shape: Neat

Molecular weight: 527.63

Ref: TR-G410500

3-Cyclohexyl-1-[4-[2-(7-methoxy -4,4-dimethyl-1,3-dioxo-isoquinolin -2-yl)ethyl]phenyl]sulfonyl-urea

CAS: 33342-05-1

3-Cyclohexyl-1-[4-[2-(7-methoxy -4,4-dimethyl-1,3-dioxo-isoquinolin -2-yl)ethyl]phenyl]sulfonyl-urea is a drug that inhibits the enzyme DPPIV, which breaks down the incretin hormone glucagon-like peptide (GLP)-1. It may be used to treat diabetes by regulating blood glucose levels. This drug has been shown to reduce postprandial blood glucose levels in patients with type 2 diabetes. 3CYCSU is also capable of reducing body weight and food intake in mice. The mechanism of action of this drug is not fully understood, but it appears to have an effect on the cytosolic calcium ion concentration and may reduce inflammatory responses in cells. 3CYCSU is a promising potential treatment for infectious diseases such as Hepatitis C virus (HCV).

Formula: C₂₇H₃₃N₃O₆S

Color and Shape: Powder

Molecular weight: 527.63 g/mol

Ref: 3D-FG40551

Gliquidone

CAS: 33342-05-1

Purity: 99%

Molecular weight: 527.209

Ref: 10-F828164

Gliquidone

CAS: 33342-05-1

Formula: C₂₇H₃₃N₃O₆S

Molecular weight: 527.64

Ref: ST-EA-CP-G70000

Gliquidone

CAS: 33342-05-1

Gliquidone

Formula: C₂₇H₃₃N₃O₆S

Purity: 99.7%

Color and Shape: White

Molecular weight: 527.20901

Ref: 47-580