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CAS 333963-40-9

:

Amitiza

Description:
Amitiza, with the chemical name lubiprostone and CAS number 333963-40-9, is a synthetic bicyclic fatty acid derivative primarily used as a medication for the treatment of chronic constipation and irritable bowel syndrome with constipation. It functions as a chloride channel activator, specifically targeting the ClC-2 channel in the gastrointestinal tract, which enhances fluid secretion and promotes bowel movement. Amitiza is typically administered orally and is known for its relatively low systemic absorption, which minimizes potential side effects. The substance is characterized by its molecular formula, which includes carbon, hydrogen, and oxygen atoms, and it exhibits a unique structure that contributes to its pharmacological activity. Common side effects may include nausea, diarrhea, and abdominal discomfort, but it is generally well-tolerated. Amitiza's mechanism of action and its role in increasing intestinal fluid secretion make it an important therapeutic option for patients suffering from specific gastrointestinal disorders.
Formula:C20H32F2O5
InChI:InChI=1S/C20H32F2O5/c1-2-3-11-19(21,22)20(26)12-10-15-14(16(23)13-17(15)27-20)8-6-4-5-7-9-18(24)25/h14-15,17,26H,2-13H2,1H3,(H,24,25)/t14-,15-,17-,20-/m1/s1
InChI key:InChIKey=WGFOBBZOWHGYQH-MXHNKVEKSA-N
SMILES:C(CCCC)(F)(F)[C@]1(O)O[C@]2([C@](CC1)([C@@H](CCCCCCC(O)=O)C(=O)C2)[H])[H]
Synonyms:
  • (11a)-16,16-Difluoro-11-hydroxy-9,15-dioxo-prostan-1-oic Acid
  • (11alpha,15R)-16,16-difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid
  • (11α,15R)-11,15-Epoxy-16,16-difluoro-15-hydroxy-9-oxoprostan-1-oic acid
  • (2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[b]pyran-5-heptanoic acid
  • (8beta,11alpha,15R)-16,16-difluoro-15-hydroxy-9-oxo-11,15-epoxyprostan-1-oic acid
  • 7-((2R,4aR,5R,7aR)-2-(1,1-Difluoropentyl)-2-hydroxy-6-oxooctahydrocyclopenta[b]pyran-5-yl)heptanoic acid
  • 7-[(1R,3R,6R,7R)-3-(1,1-Difluoropentyl)-3-hydroxy-8-oxo-2-oxabicyclo[4.3.0]non-7-yl]heptanoic acid
  • 7-[(1R,4R,6R,9R)-4-(1,1-Difluoropentyl)-4-Hydroxy-8-Oxo-5-Oxabicyclo[4.3.0]Non-9-Yl]Heptanoic Acid
  • 7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentan-1-yl)-2-hydroxy-6-oxooctahydroxypenta[b]pyran-5-yl]heptanoic acid
  • Amitiza
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