CAS 33419-42-0: Etoposide

Description: Etoposide is a chemotherapeutic agent primarily used in the treatment of various cancers, including testicular cancer and small cell lung cancer. It is classified as a topoisomerase II inhibitor, which means it interferes with the enzyme responsible for DNA replication and repair, ultimately leading to cancer cell death. Etoposide is typically administered intravenously or orally and is known for its effectiveness in combination with other chemotherapy drugs. The compound has a molecular formula of C21H22O8 and a molecular weight of approximately 366.39 g/mol. Etoposide is characterized by its ability to induce apoptosis in cancer cells, making it a valuable tool in oncology. However, it can also cause side effects, including myelosuppression, gastrointestinal disturbances, and increased risk of secondary malignancies. Due to its mechanism of action, careful monitoring and management of dosage are essential to minimize toxicity while maximizing therapeutic efficacy. Overall, etoposide remains an important agent in the arsenal against certain malignancies.

Formula: C₂₉H₃₂O₁₃

InChI: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

InChI key: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N

SMILES: O=C1OCC2C(OC3OC4COC(OC4C(O)C3O)C)C5=CC=6OCOC6C=C5C(C7=CC(OC)=C(O)C(OC)=C7)C12

Synonyms:

• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
• 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
• 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
• 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
• 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
• 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
• Beposid
• Bioposide
• Celltop
• EPE
• Epipodophyllotoxin VP 16213
• Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
• Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Eposed
• Eposin
• Ethopul
• Eto-Gry
• Etoposid
• Etoposido
• Etosid
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Fytop
• Fytosid
• Lastet
• Nsc 141540
• Nzytop
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• Sintopozid
• Topok
• Toposar
• Toposide
• VP 16 (pharmaceutical)
• VePesid
• Vepesid J
• Vp 16
• Vp 16-123
• Vp 16-213
• Zuyeyidal
• trans-Etoposide
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is used as a inhibits DNA synthesis and is very active against cells in …

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: Powder or crystals or crystalline powder
• Molecular weight: 588.56

Etoposide for system suitability CRS

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Molecular weight: 588.5566

Etoposide CRS

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: Crystalline Powder. White. Powder.
• Molecular weight: 588.5566

Etoposide

CAS: 33419-42-0

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: White Off-White Powder
• Molecular weight: 588.18429

Etoposide

CAS: 33419-42-0

Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex …

• Formula: C₂₉H₃₂O₁₃
• Purity: 99.19% - 99.94%
• Color and Shape: Crystals From Methanol Solid
• Molecular weight: 588.56

(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 588.5566

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purity: (HPLC) ≥ 98.0%
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 588.56

Etoposide, USP grade

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purity: (anhydrous basis) 95.0 - 105.0 %
• Color and Shape: White or almost white crystalline powder
• Molecular weight: 588.56

Etoposide-13C-d3

CAS: 33419-42-0

• Formula: C₂₈₁₃CH₂₉D₃O₁₃
• Color and Shape: Off-White Solid
• Molecular weight: 592.57

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: Neat
• Molecular weight: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a chemotherapy medication used for the treatments of a number of types of …

• Formula: C₂₉H₃₂O₁₃
• Purity: 95%~99%
• Molecular weight: 588.562

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: Neat
• Molecular weight: 588.56

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: White To Off-White Solid
• Molecular weight: 588.56

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Purity: By hplc: 99.51% by area. (Typical Value in Batch COA)
• Color and Shape: pale yellow solid
• Molecular weight: 588.56g/mol

Etoposide RS

CAS: 33419-42-0

• Color and Shape: White

Etoposide-d3

CAS: 33419-42-0

Applications A labelled DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. …

• Formula: C₂₉H₂₉D₃O₁₃
• Color and Shape: Neat
• Molecular weight: 591.58

Etoposide-d4

CAS: 33419-42-0

Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic …

• Formula: C₂₉H₂₈D₄O₁₃
• Color and Shape: Neat
• Molecular weight: 592.58

Etoposide

CAS: 33419-42-0

• Formula: C₂₉H₃₂O₁₃
• Color and Shape: Off-White
• Molecular weight: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition …

• Formula: C₂₉H₃₂O₁₃
• Purity: Min. 98 Area-%
• Color and Shape: White Powder
• Molecular weight: 588.55 g/mol