CAS 33419-42-0
:Etoposide
Description:
Etoposide is a chemotherapeutic agent primarily used in the treatment of various cancers, including testicular cancer and small cell lung cancer. It is classified as a topoisomerase II inhibitor, which means it interferes with the enzyme responsible for DNA replication and repair, ultimately leading to cancer cell death. Etoposide is typically administered intravenously or orally and is known for its effectiveness in combination with other chemotherapy drugs. The compound has a molecular formula of C21H22O8 and a molecular weight of approximately 366.39 g/mol. Etoposide is characterized by its ability to induce apoptosis in cancer cells, making it a valuable tool in oncology. However, it can also cause side effects, including myelosuppression, gastrointestinal disturbances, and increased risk of secondary malignancies. Due to its mechanism of action, careful monitoring and management of dosage are essential to minimize toxicity while maximizing therapeutic efficacy. Overall, etoposide remains an important agent in the arsenal against certain malignancies.
Formula:C29H32O13
InChI:InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1
InChI key:InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N
SMILES:O=C1[C@@]2([C@@H](C=3C([C@@H](O[C@@H]4O[C@]5([C@]([C@H](O)[C@H]4O)(O[C@H](C)OC5)[H])[H])[C@]2(CO1)[H])=CC6=C(C3)OCO6)C7=CC(OC)=C(O)C(OC)=C7)[H]
Synonyms:- (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
- (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
- (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
- 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
- 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
- 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
- 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
- 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
- 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
- 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
- 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
- Beposid
- Bioposide
- Celltop
- EPE
- Epipodophyllotoxin VP 16213
- Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
- Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
- Eposed
- Eposin
- Ethopul
- Eto-Gry
- Etoposid
- Etoposido
- Etosid
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
- Fytop
- Fytosid
- Lastet
- Nsc 141540
- Nzytop
- Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
- Sintopozid
- Topok
- Toposar
- Toposide
- VP 16 (pharmaceutical)
- VePesid
- Vepesid J
- Vp 16
- Vp 16-123
- Vp 16-213
- Zuyeyidal
- trans-Etoposide
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
- (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
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Etoposide
CAS:Formula:C29H32O13Purity:>98.0%(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:588.56Etoposide
CAS:<p>Topoisomerase inhibitor and inducer of apoptosis</p>Formula:C29H32O13Color and Shape:Powder or crystals or crystalline powderMolecular weight:588.56ETOPOSIDE FOR SYSTEM SUITABILITY CRS
CAS:<p>ETOPOSIDE FOR SYSTEM SUITABILITY CRS</p>Formula:C29H32O13Molecular weight:588.5566Digitoxin
CAS:DigitoxinFormula:C41H64O13Purity:97.9%Color and Shape:Off-WhiteMolecular weight:764.43469Etoposide
CAS:EtoposideFormula:C29H32O13Purity:96.2%Color and Shape:Off-WhiteMolecular weight:588.18429ETOPOSIDE CRS
CAS:<p>ETOPOSIDE CRS</p>Formula:C29H32O13Color and Shape:Crystalline Powder. White. Powder.Molecular weight:588.5566Etoposide Resolution Mixture
CAS:<p>Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives</p>Color and Shape:White PowderEtoposide
CAS:<p>Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives</p>Formula:C29H32O13Color and Shape:White Off-White PowderMolecular weight:588.18429Etoposide
CAS:<p>Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM).</p>Formula:C29H32O13Purity:99.19% - 99.94%Color and Shape:Crystals From Methanol SolidMolecular weight:588.56(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
CAS:Formula:C29H32O13Purity:98%Color and Shape:SolidMolecular weight:588.5566Etoposide
CAS:Formula:C29H32O13Purity:(HPLC) ≥ 98.0%Color and Shape:White or almost white crystalline powderMolecular weight:588.56Etoposide, USP grade
CAS:Formula:C29H32O13Purity:(anhydrous basis) 95.0 - 105.0 %Color and Shape:White or almost white crystalline powderMolecular weight:588.56Etoposide
CAS:Etoposide is a chemotherapy medication used for the treatments of a number of types of cancer. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA, it induces apoptosis in MCF-7 breast cancer cells.Formula:C29H32O13Purity:95%~99%Molecular weight:588.562Etoposide
CAS:<p>Etoposide</p>Formula:C29H32O13Purity:99%Color and Shape: pale yellow solidMolecular weight:588.56g/molEtoposide-d4
CAS:Controlled Product<p>Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. Antineoplastic.<br>References Burden, D.A., et al.: J. Biol. Chem., 271, 29238 (1996), Joel, S., et al.: Cancer Treat. Rev., 22, 179 (1996),<br></p>Formula:C29H28D4O13Color and Shape:NeatMolecular weight:592.58
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