CAS 33626-98-1

2-Naphthalenecarboxylic acid, 6-bromo-, methyl ester

Description:

2-Naphthalenecarboxylic acid, 6-bromo-, methyl ester, also known by its CAS number 33626-98-1, is an organic compound characterized by its naphthalene structure substituted with a carboxylic acid group and a bromine atom at the 6-position, along with a methyl ester functional group. This compound typically appears as a solid or crystalline substance and is soluble in organic solvents such as ethanol and acetone, but may have limited solubility in water due to its hydrophobic naphthalene ring. The presence of the bromine atom introduces notable reactivity, making it a useful intermediate in various organic synthesis reactions, including electrophilic aromatic substitution. Its ester functionality can undergo hydrolysis, transesterification, or other reactions typical of carboxylic acid derivatives. The compound may exhibit biological activity, and its derivatives are often explored in medicinal chemistry for potential therapeutic applications. Safety data should be consulted for handling, as halogenated compounds can pose environmental and health risks.

Formula: C₁₂H₉BrO₂

InChI: InChI=1S/C12H9BrO2/c1-15-12(14)10-3-2-9-7-11(13)5-4-8(9)6-10/h2-7H,1H3

InChI key: InChIKey=JEUBRLPXJZOGPX-UHFFFAOYSA-N

SMILES: C(OC)(=O)C1=CC2=C(C=C(Br)C=C2)C=C1

Synonyms:

• 2-Bromo-6-methoxycarbonylnaphthalene
• 2-Naphthalenecarboxylic acid, 6-bromo-, methyl ester
• 2-Naphthoic acid, 6-bromo-, methyl ester
• 6-Bromo-2-naphthoic acid methyl ester
• 6-Bromonaphthalene-2-carboxylic acid methyl ester
• Methyl 6-(3-benzyl-4-((2-methoxyethoxy)methoxy)phenyl)-2-naphthoate
• Methyl 6-Bromonaphthalene-2-Carboxylate
• Methyl 6-bromo-2-naphthoate

Methyl 6-Bromo-2-naphthoate

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Purity: >98.0%(GC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 265.11

Ref: 3B-B2202

Methyl 6-bromo-2-naphthoate, 98%

CAS: 33626-98-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₂H₉BrO₂

Purity: 98%

Color and Shape: White, Powder

Molecular weight: 265.11

Ref: 02-B25106

Adapalene Related Compound A (Methyl 6-bromo-2-naphthoate)

CAS: 33626-98-1

Aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacid and their derivatives, nesoi

Formula: C₁₂H₉BrO₂

Color and Shape: White Off-White Tan Powder

Molecular weight: 263.97859

Ref: 45-1011710

Methyl 6-bromo-2-naphthoate

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 265.1027

Ref: IN-DA003RYC

Methyl 6-Bromo-2-naphthoate

CAS: 33626-98-1

Methyl 6-Bromo-2-naphthoate

Purity: 98%

Molecular weight: 265.10g/mol

Ref: 54-OR350229

Methyl 6-bromo-2-naphthoate

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Molecular weight: 265.11

Ref: 7W-GK4178

Adapalene USP Related Compound A

Controlled Product

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Color and Shape: Neat

Molecular weight: 265.10

Ref: 86-MM0681.05

Methyl 6-bromo-2-Naphthoate

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Molecular weight: 265.11

Ref: 4Z-N-077057

Methyl 6-Bromo-2-napthoate

Controlled Product

CAS: 33626-98-1

Impurity Adapalene USP Related Compound A
Applications Methyl 6-Bromo-2-napthoate (Adapalene USP Related Compound A) is used in the synthesis of Adapalene, a retinoid specific for RARβ and RARγ receptors.
References Milanese, A. et al.: Bioorg. Chem., 9, 151 (2011);

Formula: C₁₂H₉BrO₂

Color and Shape: Neat

Molecular weight: 265.10

Ref: TR-M294305

Methyl 6-bromo-2-naphthoate

CAS: 33626-98-1

Methyl 6-bromo-2-naphthoate is an eluting compound that binds with a hydroxyl group to the gamma-aminobutyric acid receptor. It has been shown to have high binding constants and the ability to bind to protein data. Methyl 6-bromo-2-naphthoate has been shown to inhibit the production of GABA in fetal bovine brain slices, which may be due to its ability to bind selectively with this receptor. This agent also inhibits cell proliferation and induces cell death in culture by interacting with proteins involved in cell cycle regulation.

Formula: C₁₂H₉BrO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 265.1 g/mol

Ref: 3D-FM33203

Methyl 6-bromo-2-naphthoate

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Purity: 95%

Color and Shape: White – Pale yellow powder

Molecular weight: 265.106

Ref: 10-F212416

Adapalene USP Related Compound A

CAS: 33626-98-1

Formula: C₁₂H₉BrO₂

Molecular weight: 265.10

Ref: ST-EA-CP-A48005