CAS 33671-46-4

Clotiazepam

Description:

Clotiazepam is a benzodiazepine derivative primarily used for its anxiolytic and sedative properties. It is characterized by its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased neuronal inhibition and a calming effect on the central nervous system. Clotiazepam is typically administered in oral form and is known for its relatively rapid onset of action. The substance exhibits a moderate duration of effect, making it suitable for short-term management of anxiety and related disorders. Its chemical structure includes a thiazole ring, which contributes to its pharmacological profile. Clotiazepam is generally well-tolerated, but like other benzodiazepines, it may lead to dependence and withdrawal symptoms if used for extended periods. Side effects can include drowsiness, dizziness, and cognitive impairment. As with all medications, it is essential to use clotiazepam under medical supervision to mitigate risks and ensure appropriate therapeutic use.

Formula: C₁₆H₁₅ClN₂OS

InChI: InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3

InChI key: InChIKey=CHBRHODLKOZEPZ-UHFFFAOYSA-N

SMILES: CN1C2=C(C(=NCC1=O)C3=C(Cl)C=CC=C3)C=C(CC)S2

Synonyms:

• 1-Methyl-5-o-chlorophenyl-7-ethyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one
• 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(o-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
• 5-(2-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno[2,3-e]-1,4-diazepin-2-one
• 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1H-thieno[2,3-e][1,4]diazepin-2(3H)-one
• 5-(o-Chlorophenyl)-7-ethyl-1-methyl-1,2-dihydro-3H-thieno[2,3-e][1,4]diazepin-2-one
• Clotiazepam
• Clozan
• Rize
• Rizen
• Tienor
• Trecalmo
• Veratran
• Y 6047
• 2H-Thieno[2,3-e]-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-
• 5-(2-Chlorophenyl)-7-ethyl-1-methyl-1,3-dihydro-2H-thieno(2,3-e)(1,4)diazepin-2-one
• 5-(o-Chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl-2H-thieno[2,3-e]-1,4-diazepin-2-one

Clotiazepam, 1mg/ml in Methanol

Controlled Product

CAS: 33671-46-4

Color and Shape: Single Solution

Ref: LP-CLT-1700-1LM

Clotiazepam

Controlled Product

CAS: 33671-46-4

Color and Shape: Neat

Ref: LP-CLT-1700-10

Clotiazepam (1 mg/mL in Methanol)

Controlled Product

CAS: 33671-46-4

Formula: C₁₆H₁₅ClN₂OS

Color and Shape: Colourless

Molecular weight: 318.82

Ref: TR-KIT2090

Clotiazepam

Controlled Product

CAS: 33671-46-4

Applications A thienodiazepine derivative that possesses anxiolytic, skeletal muscle relaxant anticonvulsant, sedative properties as well as contributing to siginificant increase stage 2 NREM sleep. It binds to benzodiazepine site of the GABAA receptor where it acts as a full agonist resulting in enhanced GABA inhibitory effect at the GABAA receptor. Controlled Substance.
References Mandrioli, R. et al.: Curr.Drug Metab., 8, 827 (2008); Nakazawa, Y. et al.: Psychopharmacol., 44, 165 (1975); Yakushiji, T. et al.: Br. J. Pharmacol., 98, 735 (1989);

Formula: C₁₆H₁₅ClN₂OS

Color and Shape: Off-White

Molecular weight: 318.82

Ref: TR-C587410

Clotiazepam (1 mg/ml in Acetonitrile)

Controlled Product

CAS: 33671-46-4

Formula: C₁₆H₁₅ClN₂OS

Color and Shape: Single Solution

Molecular weight: 318.82

Ref: TR-KIT3780