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CAS 3374-05-8

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Nalidixic acid sodium salt

Description:
Nalidixic acid sodium salt is a synthetic antibacterial agent belonging to the quinolone class of antibiotics. It is primarily used to treat urinary tract infections caused by susceptible bacteria. The compound is characterized by its ability to inhibit bacterial DNA gyrase, an enzyme crucial for DNA replication and transcription, thereby exerting its antimicrobial effects. Nalidixic acid sodium salt is typically presented as a white to off-white crystalline powder, soluble in water, which enhances its bioavailability for therapeutic use. The substance has a relatively low toxicity profile, but its use is generally limited to specific infections due to the development of bacterial resistance. It is important to note that while nalidixic acid is effective against certain Gram-negative bacteria, it is less effective against Gram-positive organisms. As with all antibiotics, appropriate susceptibility testing is recommended to ensure efficacy and minimize resistance development. Additionally, potential side effects may include gastrointestinal disturbances and hypersensitivity reactions, necessitating careful monitoring during treatment.
Formula:C12H11N2NaO3
InChI:InChI=1/C12H12N2O3.Na/c1-3-14-6-9(12(16)17)10(15)8-5-4-7(2)13-11(8)14;/h4-6H,3H2,1-2H3,(H,16,17);/q;+1/p-1
InChI key:InChIKey=MOPGPFXSCUGEEH-UHFFFAOYSA-N
SMILES:C(C)N1C=2C(C(=O)C(C(O)=O)=C1)=CC=C(C)N2.[Na]
Synonyms:
  • 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt
  • 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt (1:1)
  • Nalidixate sodium
  • Nalidixic Acid Sodium
  • Nalidixic Acid Sodium Gamma-Irradiated*Molecular
  • Sodium 1-Ethyl-7-Methyl-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylate
  • Sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate
  • Sodium nalidixate
  • Win 18320-3
  • 1,4-Dihydro-1-ethyl-4-oxo-7-methyl-1,8-naphthyridine-3-carboxylic acid sodium salt
  • See more synonyms
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