CAS 338-95-4

Isoflupredone

Description:

Isoflupredone, with the CAS number 338-95-4, is a synthetic corticosteroid that exhibits anti-inflammatory and immunosuppressive properties. It is characterized by its ability to modulate the immune response and reduce inflammation, making it useful in various therapeutic applications, particularly in treating conditions such as allergies, asthma, and autoimmune disorders. Isoflupredone is typically administered in a pharmaceutical formulation, often as an injectable or topical agent. Its mechanism of action involves binding to glucocorticoid receptors, leading to the regulation of gene expression that ultimately decreases the production of pro-inflammatory cytokines. The substance is known for its potency and relatively low mineralocorticoid activity, which minimizes fluid retention and other side effects commonly associated with corticosteroids. Isoflupredone's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are influenced by its chemical structure, which allows for effective therapeutic use while managing potential adverse effects. As with all corticosteroids, careful consideration of dosage and duration of treatment is essential to minimize risks associated with long-term use.

Formula: C₂₁H₂₇FO₅

InChI: InChI=1/C21H27FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h5,7,9,14-16,23,25,27H,3-4,6,8,10-11H2,1-2H3

InChI key: InChIKey=WAIJIHDWAKJCBX-BULBTXNYSA-N

SMILES: F[C@@]12[C@]([C@]3([C@](C)(C[C@@H]1O)[C@](C(CO)=O)(O)CC3)[H])(CCC=4[C@]2(C)C=CC(=O)C4)[H]

Synonyms:

• (11Beta)-9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
• (11β)-9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
• (8Xi,10Xi,11Beta,13Xi,14Xi,17Xi)-9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
• 9-Fluoro-11,17,21-Trihydroxypregna-1,4-Diene-3,20-Dione
• 9-Fluoroprednisolone
• 9α-Fluoro-Δ¹-cortisol
• Isoflupredone
• NSC 12174
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11β)-
• Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-
• Δ-Fluorocortisone
• 9α-Fluoro-Δ1-cortisol
• 1,4-PREGNADIEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE
• 9-Fluoro-11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
• (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
• 9-Fluoro-11β,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
• 1,4-PREGNADIEN-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
• 9α-Fluoro-1-cortisol
• 9a-fluoroprednisolone
• DELTAFLUDROCORTISONE
• (11β)-9-Fluoro-11,17,21-trihydroxy-pregna-1,4-diene-3,20-dione
• 9-ALPHA-FLUOROPREDNISOLONE
• Isoflupredone USP/EP/BP

(11β)-9-Fluoro-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

CAS: 338-95-4

Purity: 98%

Ref: IN-DA007IKG

Isoflupredone

CAS: 338-95-4

Isoflupredone

Formula: C₂₁H₂₇FO₅

Purity: ≥95%

Molecular weight: 378.43

Ref: 54-BUP11502

Isoflupredone

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Color and Shape: White To Off-White Solid

Molecular weight: 378.44

Ref: 4Z-I-082002

Isoflupredone 100 µg/mL in Acetonitrile

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Color and Shape: Single Solution

Molecular weight: 378.43

Ref: 04-A14424900AL-100

Isoflupredone 100 µg/mL in Methanol

Controlled Product

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Color and Shape: Single Solution

Molecular weight: 378.43

Ref: 04-A14424900ME-100

Isoflupredone

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Color and Shape: Neat

Molecular weight: 378.43

Ref: 04-C14424900

Isoflupredone

Controlled Product

CAS: 338-95-4

Applications Anti-inflammatory.
References Buchwald, P., et al.: Steroids, 73, 193 (2008), Holbeck, S., et al.: Mol. Endocrinol., 24, 1287 (2010),

Formula: C₂₁H₂₇FO₅

Color and Shape: Neat

Molecular weight: 378.43

Ref: TR-I816600

Isoflupredone-d3 (d2 Major)

Controlled Product

CAS: 338-95-4

Applications Labelled Isoflupredone (I816600). Anti-inflammatory.
References Buchwald, P., et al.: Steroids, 73, 193 (2008), Holbeck, S., et al.: Mol. Endocrinol., 24, 1287 (2010),

Formula: C₂₁H₂₄D₃FO₅

Color and Shape: Neat

Molecular weight: 381.45

Ref: TR-I816602

Isoflupredone

Controlled Product

CAS: 338-95-4

Isoflupredone is a nonsteroidal anti-inflammatory drug that is used for the treatment of inflammation and pain. It works by inhibiting the production of prostaglandin, which is a hormone that causes inflammation and pain. Isoflupredone has been shown to decrease cortisol concentration in rats and reduce the amount of hydrogen fluoride needed to inhibit bacterial growth. Isoflupredone also inhibits the activity of toll-like receptor 2, which plays an important role in inflammatory responses.

Formula: C₂₁H₂₇FO₅

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 378.43 g/mol

Ref: 3D-FI24676

Isoflupredone in Methanol

CAS: 338-95-4

Methanol

Formula: C₂₁H₂₇FO₅

Molecular weight: 378.4

Ref: BE-BePure-27274XM-100

Isoflupredone

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Molecular weight: 378.4

Ref: BE-BePure-27274

Isoflupredone

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Molecular weight: 378.4

Ref: BE-RMCI117000

Isoflupredone in Acetonitrile

CAS: 338-95-4

Acetonitrile

Formula: C₂₁H₂₇FO₅

Molecular weight: 378.4

Ref: BE-BePure-27274XA-100

Isoflupredone

CAS: 338-95-4

Isoflupredone, a synthetic corticosteroid, inhibits inflammation and immune response in animals.

Formula: C₂₁H₂₇FO₅

Purity: 97.62% - 99.85%

Color and Shape: Solid

Molecular weight: 378.43

Ref: TM-T41303

Betamethasone EP Impurity K

CAS: 338-95-4

Formula: C₂₁H₂₇FO₅

Molecular weight: 378.43

Ref: ST-EA-CP-B25070