CAS 33818-15-4

Citicoline sodium

Description:

Citicoline sodium, also known as cytidine diphosphate choline, is a naturally occurring compound that plays a crucial role in the synthesis of phospholipids, particularly phosphatidylcholine, which is essential for cell membrane integrity and function. It is a sodium salt of citicoline, characterized by its ability to enhance cognitive function and support neuronal health. Citicoline is often used as a nootropic agent, believed to improve memory and cognitive performance, particularly in conditions such as stroke, traumatic brain injury, and age-related cognitive decline. The substance is water-soluble, making it easily absorbed in the gastrointestinal tract. It is generally well-tolerated, with a favorable safety profile, and side effects are typically mild, including gastrointestinal discomfort. Citicoline sodium is available in various formulations, including oral tablets and injectable forms, and is often utilized in dietary supplements and pharmaceutical preparations aimed at enhancing cognitive function and neuroprotection. Its mechanism of action involves the modulation of neurotransmitter levels and the promotion of neuronal membrane repair.

Formula: C₁₄H₂₆N₄O₁₁P₂·Na

InChI: InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/t9-,11-,12-,13-;/m1./s1

InChI key: InChIKey=GBRJGMTWFZWCCU-OCMLZEEQSA-N

SMILES: O[C@H]1[C@@H](O[C@H](COP(OP(OCC[N+](C)(C)C)(=O)[O-])(=O)O)[C@H]1O)N2C(=O)N=C(N)C=C2.[Na]

Synonyms:

• Acticolin
• Brassel
• Cebroton
• CerAxon
• Choline, hydroxide, monoester with cytidine 5′-(trihydrogen pyrophosphate), inner salt, monosodium salt
• Cidifos
• Citicoline Sodium
• Cytidine 5'-(Trihydrogen Diphosphate) P'-(2-(Trimethylammonio)Ethyl) Ester Inner Salt Monosodium Salt
• Cytidine 5′-(trihydrogen diphosphate), P′-[2-(trimethylammonio)ethyl] ester, hydroxide, inner salt, monosodium salt
• Cytidine 5′-(trihydrogen diphosphate), P′-[2-(trimethylammonio)ethyl] ester, inner salt, sodium salt (1:1)
• Flussorex
• Gerolin
• IP 302 sodium
• Logan
• Neurotron
• Sinkron
• Strolin

Cytidine-5'-diphosphocholine sodium salt

CAS: 33818-15-4

Intermediate in the synthesis of phosphatidylcholine; also a phospholipase inhibitor

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Color and Shape: White, Powder or crystals or crystalline powder

Molecular weight: 510.31

Ref: 02-J64161

Citicoline Sodium

CAS: 33818-15-4

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Color and Shape: White Powder

Molecular weight: 510.08928

Ref: 45-1134305

sodium 2-(trimethylazaniumyl)ethyl ({[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphonato}oxy)phosphonate

CAS: 33818-15-4

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 510.3058

Ref: IN-DA003P0A

Citicoline Sodium

CAS: 33818-15-4

Citicoline Sodium

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: 97%

Molecular weight: 510.31

Ref: 54-OR1012699

Citicoline sodium

CAS: 33818-15-4

Citicoline sodium aids in making phosphatidylcholine and acetylcholine, protects the brain from trauma, and improves memory.

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: 99.26% - 99.37%

Color and Shape: White Solid

Molecular weight: 510.31

Ref: TM-T1208

Citicoline sodium

CAS: 33818-15-4

Citicoline sodium

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: ≥98%

Molecular weight: 510.31

Ref: 54-BUP15902

Citicoline sodium salt

CAS: 33818-15-4

2-(((((((2R,3S,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)-N,N,N-trimethylethan-1-aminium, sodium salt(1:1)

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: 97%

Molecular weight: 510.31

Ref: IN-DG121806

Citicoline sodium salt

CAS: 33818-15-4

Formula: C₁₄H₂₅N₄NaO₁₁P₂·xH₂O

Purity: ≥ 98.0% (anhydrous basis)

Color and Shape: White to almost white crystalline powder

Molecular weight: 511.31 (anhydrous)

Ref: 7W-GP4568

Citicoline Sodium Salt (CDP-Choline Sodium Salt)

CAS: 33818-15-4

Formula: C₁₄H₂₅N₄O₁₁P₂·Na

Molecular weight: 487.32 22.99

Ref: 4Z-C-452001

Citicoline sodium

CAS: 33818-15-4

Formula: C₁₄H₂₅N₄O₁₁P₂·Na

Color and Shape: White

Molecular weight: 510.31

Ref: 04-C11668507

Citicoline Sodium

CAS: 33818-15-4

Color and Shape: White

Ref: 86-MM3913.00

Cytidine 5'-Diphosphocholine Sodium Salt

CAS: 33818-15-4, 987-78-0

Formula: C₁₄H₂₅N₄NaO₁₁P₂

Purity: >95.0%(T)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 510.31

Ref: 3B-C3445

Citicoline Sodium

CAS: 33818-15-4

Formula: C₁₄H₂₆N₄NaO₁₁P₂

Molecular weight: 511.32

Ref: ST-EA-CP-C79000

Citicoline-d9 Sodium Salt

Controlled Product

CAS: 33818-15-4

Applications Labelled Citicoline (C508050). Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma.
References Kennedy, E.P., et al.: J. Biol. Chem., 222, 185 (1956), Rao, A., et al.: J. Neurosci. Res., 58, 697 (1999), Wurtman, R., et al.: Biochem. Pharmacol., 60, 989 (2000),

Formula: C₁₄D₉H₁₆N₄NaO₁₁P₂

Color and Shape: Neat

Molecular weight: 519.361

Ref: TR-C508052

Citicoline Sodium Salt

CAS: 33818-15-4

Applications Naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotective product. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor) (1). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats. (2). Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidative stress and NO overproduction in the hippocampus.
References Castagna A, et al. Clin Drug Investig. 2016 Sep 1 Abdolmaleki A, et al. 2016. Eur J Pharmacol. Oct 15;789:275-9Abdel-Zaher AO et al. Toxicol Ind Health. 2016 May 13

Formula: C₁₄H₂₅N₄O₁₁P₂·Na

Color and Shape: Neat

Molecular weight: 510.31

Ref: TR-C508050

Citicoline sodium

CAS: 33818-15-4

Citicoline is a complex organic molecule, a form of B-vitamin choline that acts as an intermediate in many biosynthetic pathways, for example, in the biosynthesis of cell membrane phospholipids. As a dietary supplement, citicoline is a source of choline and cytidine, two components that are quickly absorbed in the intestine and across the blood-brain barrier. The neuroprotective properties of citicoline improves mental performance increasing the levels of other brain-related chemicals like dopamine and norepinephrine, helping with recovery in stroke patients, reducing memory loss due to aging and improving vision in patients with glaucoma.

Formula: C₁₄H₂₆N₄O₁₁P₂•Na

Purity: Min. 98.0 Area-%

Color and Shape: White To Off-White Solid

Molecular weight: 511.31 g/mol

Ref: 3D-NC05679

Citicoline sodium

CAS: 33818-15-4

Purity: 97%

Molecular weight: 510.3080139

Ref: 10-F868781