CAS 341031-54-7: Sunitinib malate

Description:Sunitinib malate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including renal cell carcinoma and gastrointestinal stromal tumors. It functions by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis. The substance appears as a yellow to orange crystalline powder and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and methanol, but has limited solubility in water. Its molecular formula reflects a complex structure that includes a pyrrole ring and a substituted phenyl group, contributing to its pharmacological activity. Sunitinib malate is administered orally and is known for its side effects, which can include fatigue, diarrhea, and hypertension, among others. The malate salt form enhances its stability and bioavailability. As a targeted therapy, it represents a significant advancement in cancer treatment, focusing on inhibiting specific pathways that promote tumor growth rather than broadly affecting all rapidly dividing cells.

Formula:C₂₂H₂₇FN₄O₂·C₄H₆O₅

InChI:InChI=1/C23H30N4O2.C5H8O5/c1-6-27(7-2)11-10-24-23(29)21-15(4)20(25-16(21)5)13-18-17-12-14(3)8-9-19(17)26-22(18)28;6-3(5(9)10)1-2-4(7)8/h8-9,12-13,25H,6-7,10-11H2,1-5H3,(H,24,29)(H,26,28);3,6H,1-2H2,(H,7,8)(H,9,10)/b18-13-;/t;3-/m.0/s1

SMILES:O=C(O)CC(O)C(=O)O.O=C1NC2=CC=C(F)C=C2C1=CC=3NC(=C(C(=O)NCCN(CC)CC)C3C)C

Synonyms:
(2S)-2-hydroxybutanedioic acid - N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4- dimethyl-, (2S)-hydroxybutanedioate (1:1)
2-hydroxypentanedioic acid - N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-[(Z)-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxamide (1:1)
Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2- (diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H- indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide (1:1)
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
Su 011248
Su 11248
Sunitinib <span class="text-smallcaps">L</span>-malate
Sunitinib L-malate
See more synonyms
Sunitinib Mablate
Sunitinib Maleate
Sutent
Sunitinib malate

Found 11 products.

Product data	Purity	Price range	Estimated delivery
Sunitinib Malate REF: 45-1642358CAS: 341031-54-7	- - -	1,716.00 €	Thu 10 Apr 25
Sunitinib Malate REF: TM-T0374CAS: 341031-54-7	98% - 99.26%	44.00 €~87.00 €	Fri 11 Apr 25
Sunitinib malate REF: 7W-GP2160CAS: 341031-54-7	≥ 99.0% (dried basis)	63.00 €~148.00 €	Mon 14 Apr 25
Sunitinib Impurity 2 REF: 4Z-S-4117CAS: 341031-54-7	- - -	To inquire	Mon 14 Apr 25
Sunitinib Malate REF: 54-PC105431CAS: 341031-54-7	98%	32.00 €~1,056.00 €	Mon 14 Apr 25
Sunitinib Malate REF: 4Z-S-411CAS: 341031-54-7	- - -	To inquire	Mon 14 Apr 25
Sunitinib Malate (Sunitinib L-Malate) REF: 86-MM3568.00CAS: 341031-54-7	- - -	1,455.00 €	Mon 14 Apr 25
Sunitinib Malate REF: 3B-U0095CAS: 341031-54-7 557795-19-4	>98.0%(HPLC)	139.00 €	Mon 14 Apr 25
Sunitinib malate REF: AC-46264CAS: 341031-54-7	- - -	To inquire	Mon 14 Apr 25
Sunitinib malate - Bio-X ™ REF: 3D-BS164428CAS: 341031-54-7	Min. 95%	147.00 €	Tue 22 Apr 25
Sunitinib malate REF: 3D-FS10822CAS: 341031-54-7	Min. 95%	143.00 €~1,326.00 €	Tue 22 Apr 25