CAS 341031-54-7

Sunitinib malate

Description:

Sunitinib malate is a small molecule tyrosine kinase inhibitor primarily used in the treatment of certain types of cancer, including renal cell carcinoma and gastrointestinal stromal tumors. It functions by inhibiting multiple receptor tyrosine kinases, which are involved in tumor growth and angiogenesis. The substance appears as a yellow to orange crystalline powder and is soluble in organic solvents like dimethyl sulfoxide (DMSO) and methanol, but has limited solubility in water. Its molecular formula reflects a complex structure that includes a pyrrole ring and a substituted phenyl group, contributing to its pharmacological activity. Sunitinib malate is administered orally and is known for its side effects, which can include fatigue, diarrhea, and hypertension, among others. The malate salt form enhances its stability and bioavailability. As a targeted therapy, it represents a significant advancement in cancer treatment, focusing on inhibiting specific pathways that promote tumor growth rather than broadly affecting all rapidly dividing cells.

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

InChI: InChI=1/C23H30N4O2.C5H8O5/c1-6-27(7-2)11-10-24-23(29)21-15(4)20(25-16(21)5)13-18-17-12-14(3)8-9-19(17)26-22(18)28;6-3(5(9)10)1-2-4(7)8/h8-9,12-13,25H,6-7,10-11H2,1-5H3,(H,24,29)(H,26,28);3,6H,1-2H2,(H,7,8)(H,9,10)/b18-13-;/t;3-/m.0/s1

SMILES: C(=C\1/C=2C(NC1=O)=CC=C(F)C2)\C3=C(C)C(C(NCCN(CC)CC)=O)=C(C)N3.[C@H](CC(O)=O)(C(O)=O)O

Synonyms:

• (2S)-2-hydroxybutanedioic acid - N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
• 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4- dimethyl-, (2S)-hydroxybutanedioate (1:1)
• 2-hydroxypentanedioic acid - N-[2-(diethylamino)ethyl]-2,4-dimethyl-5-[(Z)-(5-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-1H-pyrrole-3-carboxamide (1:1)
• Butanedioic acid, 2-hydroxy-, (2S)-, compd. with N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1)
• Butanedioic acid, hydroxy-, (2S)-, compd. with N-(2- (diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H- indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3- carboxamide (1:1)
• N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
• Su 011248
• Su 11248
• Sunitinib <span class="text-smallcaps">L</span>-malate
• Sunitinib L-malate
• Sunitinib Mablate
• Sunitinib Maleate
• Sutent

Sunitinib Malate

CAS: 341031-54-7

Lactams not elsewhere specified or included

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Color and Shape: Yellow Orange Powder

Molecular weight: 532.23333

Ref: 45-1642358

Sunitinib Malate

CAS: 341031-54-7

Sunitinib Malate (Sunitinib) is an indolinone-based tyrosine kinase inhibitor.

Formula: C₂₆H₃₃FN₄O₇

Purity: 98% - 99.26%

Color and Shape: Solid

Molecular weight: 532.56

Ref: TM-T0374

Sunitinib Malate

CAS: 341031-54-7

(Z)-N-(2-(Diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (S)-2-hydroxysuccinate

Formula: C₂₆H₃₃FN₄O₇

Purity: 98%

Molecular weight: 532.56

Ref: IN-DG166993

Sunitinib malate

CAS: 341031-54-7

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Purity: ≥ 99.0% (dried basis)

Color and Shape: Yellow to orange powder

Molecular weight: 532.56

Ref: 7W-GP2160

Sunitinib Impurity 2

CAS: 341031-54-7

Formula: C₂₃H₂₉FN₄O₂

Color and Shape: Orange Solid

Molecular weight: 412.51

Ref: 4Z-S-4117

Sunitinib Malate

CAS: 341031-54-7

Sunitinib Malate

Formula: C₂₆H₃₃FN₄O₇

Purity: 98%

Molecular weight: 532.57

Ref: 54-PC105431

Sunitinib Malate

CAS: 341031-54-7

Sunitinib Malate

Formula: C₂₆H₃₃FN₄O₇

Purity: ≥98%

Molecular weight: 532.56

Ref: 54-BUP14984

Sunitinib Malate

CAS: 341031-54-7

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Color and Shape: Yellow Solid

Molecular weight: 398.48 134.09

Ref: 4Z-S-411

Sunitinib Malate (Sunitinib L-Malate)

Controlled Product

CAS: 341031-54-7

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Color and Shape: Orange

Molecular weight: 532.56

Ref: 86-MM3568.00

Sunitinib Malate

CAS: 341031-54-7, 557795-19-4

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 532.57

Ref: 3B-U0095

Sunitinib L-Malate

CAS: 341031-54-7

Formula: C₂₂H₂₇FN₄O₂C₄H₆O₅

Molecular weight: 398.5 : 134.1

Ref: ST-EA-CP-S42008

Sunitinib malate - Bio-X ™

CAS: 341031-54-7

Sunitinib is a receptor tyrosine kinase inhibitor and a chemotherapeutic agent used for the treatment of renal cell carcinoma. This drug can also be used to treat gastrointestinal tumors that are resistant to imatinib. Sunitinib inhibits VEGFR1, VEGFR2, VEGFR3, PDGFR and KIT tyrosine kinases.

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 532.56 g/mol

Ref: 3D-BS164428

Sunitinib malate

CAS: 341031-54-7

Inhibits VEGFR1, VEGFR2, VEGFR3, PDGFR and KIT tyrosine kinases

Formula: C₂₂H₂₇FN₄O₂·C₄H₆O₅

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 532.56 g/mol

Ref: 3D-FS10822