CAS 342795-08-8

6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one

Description:

6-Methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one, with the CAS number 342795-08-8, is a synthetic organic compound belonging to the class of chromones, which are characterized by a benzopyranone structure. This compound features a methoxy group (-OCH3) and a nitro group (-NO2) at specific positions on the chromone ring, as well as a trifluoromethyl group (-CF3) that enhances its lipophilicity and potentially its biological activity. The presence of these functional groups suggests that it may exhibit interesting pharmacological properties, possibly including anti-inflammatory or antimicrobial activities. The trifluoromethyl group can also influence the compound's electronic properties, making it a subject of interest in medicinal chemistry. Additionally, the compound's stability and reactivity can be affected by the electron-withdrawing nature of the nitro and trifluoromethyl groups. Overall, this compound's unique structure and functionalization make it a valuable candidate for further research in various chemical and biological applications.

Formula: C₁₁H₆F₃NO₅

InChI: InChI=1S/C11H6F3NO5/c1-19-7-3-2-6-9(10(7)15(17)18)5(16)4-8(20-6)11(12,13)14/h2-4H,1H3

InChI key: WJUILHMXVGFAIS-UHFFFAOYSA-N

SMILES: COC1=C(C2=C(C=C1)OC(=CC2=O)C(F)(F)F)[N+](=O)[O-]

Synonyms:

• 4H-1-Benzopyran-4-one, 6-methoxy-5-nitro-2-(trifluoromethyl)-
• BRAGSIN2;BRAGSIN-2;BRAGSIN 2
• Bragsin2
• Bragsin 2 NEW
• 6-methoxy-5-nitro-2-(trifluoromethyl)chromen-4-one

Bragsin2

CAS: 342795-08-8

Bragsin2

Formula: C₁₁H₆F₃NO₅

Purity: 99.5%

Molecular weight: 289.16

Ref: 54-BUP06257

Bragsin2

CAS: 342795-08-8

Bragsin2, a cell-penetrant inhibitor of BRAG2 (IC50: 3 μM), blocks Arf GTPase activation, targeting the interface between BRAG2's domain and lipid bilayer.

Formula: C₁₁H₆F₃NO₅

Purity: 99.87%

Color and Shape: Solid

Molecular weight: 289.1642

Ref: TM-T14775

Bragsin2

CAS: 342795-08-8

Formula: C₁₁H₆F₃NO₅

Molecular weight: 289.1642

Ref: IN-DA01FW6T

Bragsin 2

CAS: 342795-08-8

Inhibitor of BRAG2-mediated activation of Arf GTP-ase. In vitro experiments showed that Bragsin2 inhibits the Arf GTP-ase activation that is mediated by a nucleotide exchange factor BRAG2 in a membrane-dependent manner. Bragsin2 interacts with the PH domain of BRAG2 protein as well as membrane, which prevents the activation of lipidated Arf. Bragsin2 affects the trans-Golgi network and was shown to affect the tumour sphere in breast cancer cell lines.

Formula: C₁₁H₆F₃NO₅

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 289.16 g/mol

Ref: 3D-BB168529