CAS 34408-14-5

8-chloro-9-pentofuranosyl-9H-purin-6-amine

Description:

8-Chloro-9-pentofuranosyl-9H-purin-6-amine, with the CAS number 34408-14-5, is a purine nucleoside analog characterized by its structural features that include a furanosyl sugar moiety and a chlorine substituent at the 8-position of the purine ring. This compound is known for its potential biological activity, particularly in the context of antiviral and anticancer research, as it can interfere with nucleic acid synthesis. The presence of the chlorine atom may enhance its binding affinity to specific biological targets, influencing its pharmacological properties. Additionally, the furanosyl component contributes to its solubility and stability in biological systems. As a nucleoside analog, it may mimic natural nucleosides, allowing it to be incorporated into nucleic acids, which can disrupt normal cellular processes. Overall, 8-chloro-9-pentofuranosyl-9H-purin-6-amine represents a significant compound in medicinal chemistry, with ongoing studies to elucidate its mechanisms of action and therapeutic potential.

Formula: C₁₀H₁₂ClN₅O₄

InChI: InChI=1/C10H12ClN5O4/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,13,14)

SMILES: C(C1C(C(C(n2c3c(c(N)ncn3)nc2Cl)O1)O)O)O

8-Chloroadenosine

CAS: 34408-14-5

Formula: C₁₀H₁₂ClN₅O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 301.6864

Ref: IN-DA00BYFI

8-Chloroadenosine

CAS: 34408-14-5

Formula: C₁₀H₁₂ClN₅O₄

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 301.69

Ref: 7W-GN7493

8-Chloroadenosine

CAS: 34408-14-5

8-Chloroadenosine

Purity: ≥98%

Molecular weight: 301.69g/mol

Ref: 54-BUP12100

8-Chloroadenosine

CAS: 34408-14-5

8-Chloroadenosine (NSC-354258) is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.

Formula: C₁₀H₁₂ClN₅O₄

Purity: 98.75% - 99.84%

Color and Shape: Solid

Molecular weight: 301.69

Ref: TM-T19661

8-Chloroadenosine

CAS: 34408-14-5

8-Chloroadenosine is a potent inhibitor of apoptosis, which is the process by which cells die. It has been shown to inhibit cell growth in murine hepatoma cells and synergize with other cytotoxic agents. 8-Chloroadenosine inhibits the activity of bcl-2 protein and thus blocks the release of cytochrome c from mitochondria. This causes DNA damage by inhibiting DNA synthesis and protein synthesis, leading to apoptosis. 8-Chloroadenosine has also been shown to be an active inhibitor of cancer cells, especially myeloma cell lines. The response element for 8-chloroadenosine is located in the promoter region of the gene encoding cyclooxygenase 2 (COX-2), which encodes a protein that produces prostaglandins involved in inflammation and tumor growth. The concentration of camp in cancer tissues determines whether these cells will respond favorably or unfavorably to this drug.

Formula: C₁₀H₁₂ClN₅O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 301.69 g/mol

Ref: 3D-NC03343

8-CHLOROADENOSINE

CAS: 34408-14-5

Purity: 98%

Molecular weight: 301.6900024

Ref: 10-F800242

8-Chloroadenosine

Controlled Product

CAS: 34408-14-5

Formula: C₁₀H₁₂ClN₅O₄

Color and Shape: Neat

Molecular weight: 301.686

Ref: TR-C364113