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CAS 344423-98-9

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Atorvastatin hemicalcium trihydrate

Description:
Atorvastatin hemicalcium trihydrate is a pharmaceutical compound primarily used as a lipid-lowering agent to manage cholesterol levels and reduce the risk of cardiovascular diseases. It is a calcium salt of atorvastatin, which belongs to the class of statins. The substance is characterized by its ability to inhibit HMG-CoA reductase, an enzyme crucial in the cholesterol biosynthesis pathway. This inhibition leads to a decrease in low-density lipoprotein (LDL) cholesterol and triglycerides while increasing high-density lipoprotein (HDL) cholesterol. Atorvastatin hemicalcium trihydrate is typically presented as a white to off-white crystalline powder, which is soluble in organic solvents but has limited solubility in water. The trihydrate form indicates the presence of three water molecules associated with each molecule of atorvastatin hemicalcium, which can influence its stability and bioavailability. As with many medications, it is essential to consider potential side effects and contraindications when prescribing atorvastatin, including interactions with other drugs and the need for monitoring liver function during treatment.
Formula:C33H35FN2O5CaH2O
InChI:InChI=1S/C33H35FN2O5.Ca.H2O/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;1H2/t26-,27-;;/m1../s1
InChI key:InChIKey=IHXNSKSKVAAEPI-AJUXDCMMSA-N
SMILES:C(NC1=CC=CC=C1)(=O)C=2C(=C(N(CC[C@H](C[C@H](CC(O)=O)O)O)C2C(C)C)C3=CC=C(F)C=C3)C4=CC=CC=C4.[Ca].O
Synonyms:
  • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt (2:1), trihydrate, (βR,δR)-
  • 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-, calcium salt, hydrate (2:1:3), (βR,δR)-
  • Atorvastatin Calcium Trihydrate
  • Atorvastatin calcium sesquihydrate
  • Atorvastatin hemicalcium sesquihydrate
  • Atorvastatin hemicalcium trihydrate
  • Lipitor
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