CAS 34580-13-7

Ketotifen

Description:

Ketotifen is a pharmaceutical compound primarily used as an antihistamine and mast cell stabilizer, commonly prescribed for the management of allergic conditions such as asthma and allergic rhinitis. It is classified as a dibenzocycloheptene derivative and exhibits a dual mechanism of action: it antagonizes histamine H1 receptors and inhibits the release of inflammatory mediators from mast cells. Ketotifen is typically administered in its fumarate salt form, which enhances its solubility and bioavailability. The substance is characterized by its relatively low solubility in water, but it is soluble in organic solvents. Ketotifen has a moderate half-life, allowing for once or twice daily dosing in clinical settings. Side effects may include sedation, dry mouth, and gastrointestinal disturbances, which are common among antihistamines. Its safety profile has been established through extensive clinical use, making it a well-tolerated option for long-term management of allergic conditions. As with any medication, it is essential to use Ketotifen under the guidance of a healthcare professional.

Formula: C₁₉H₁₉NOS

InChI: InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3

InChI key: InChIKey=ZCVMWBYGMWKGHF-UHFFFAOYSA-N

SMILES: O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2

Synonyms:

• 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
• 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one
• 4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one
• Brn 3983897
• Hc 20-511
• Hsdb 7283
• Ketotifen Free Base
• Ketotifen [INN:BAN]
• Ketotifene
• Ketotifene [INN-French]
• Ketotifeno
• Ketotifeno [INN-Spanish]
• Ketotifenum
• Ketotifenum [INN-Latin]
• RS-ketotifen
• Unii-X49220T18G

4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one

CAS: 34580-13-7

Formula: C₁₉H₁₉NOS

Purity: 98%

Color and Shape: Solid

Molecular weight: 309.4253

Ref: IN-DA00BZGX

Ketotifen

CAS: 34580-13-7

Formula: C₁₉H₁₉NOS

Purity: ≥ 95.0%

Color and Shape: Off-white to pale yellow or orange powder or solid

Molecular weight: 309.43

Ref: 7W-GP7774

Ketotifen

Controlled Product

CAS: 34580-13-7

Formula: C₁₉H₁₉NOS

Color and Shape: Neat

Molecular weight: 309.43

Ref: 86-MM0180.04

Ketotifen

Controlled Product

CAS: 34580-13-7

Applications Ketotifen is an intermediate in the synthesis of Ketotifen N-Oxide Hydrochloride (K315410), which is a metabolite of Ketotifen (K315100) in humans; formed by human liver microsome. For the free base, see K315115.
References Le Bigot, J.F., et al.: Drug Metab. Dispos., 11, 585 (1983); Le Bigot, J.F., et al.: Life Sci., 40, 883 (1987)

Formula: C₁₉H₁₉NOS

Color and Shape: Yellow-Orange

Molecular weight: 309.43

Ref: TR-K315413

Ketotifen

CAS: 34580-13-7

Ketotifen: Oral H1 blocker & mast cell stabilizer, inhibits 6-phosphogluconate dehydrogenase, antiviral, for EAE & asthma prevention research.

Formula: C₁₉H₁₉NOS

Color and Shape: Solid

Molecular weight: 309.43

Ref: TM-T73336

Ketotifen

CAS: 34580-13-7

Color and Shape: Neat

Ref: 61-FOR0180.04