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CAS 34580-13-7

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Ketotifen

Description:
Ketotifen is a pharmaceutical compound primarily used as an antihistamine and mast cell stabilizer, commonly prescribed for the management of allergic conditions such as asthma and allergic rhinitis. It is classified as a dibenzocycloheptene derivative and exhibits a dual mechanism of action: it antagonizes histamine H1 receptors and inhibits the release of inflammatory mediators from mast cells. Ketotifen is typically administered in its fumarate salt form, which enhances its solubility and bioavailability. The substance is characterized by its relatively low solubility in water, but it is soluble in organic solvents. Ketotifen has a moderate half-life, allowing for once or twice daily dosing in clinical settings. Side effects may include sedation, dry mouth, and gastrointestinal disturbances, which are common among antihistamines. Its safety profile has been established through extensive clinical use, making it a well-tolerated option for long-term management of allergic conditions. As with any medication, it is essential to use Ketotifen under the guidance of a healthcare professional.
Formula:C19H19NOS
InChI:InChI=1S/C19H19NOS/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19/h2-5,8,11H,6-7,9-10,12H2,1H3
InChI key:InChIKey=ZCVMWBYGMWKGHF-UHFFFAOYSA-N
SMILES:O=C1C2=C(C(C=3C(C1)=CC=CC3)=C4CCN(C)CC4)C=CS2
Synonyms:
  • 10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-
  • 4,9-Dihydro-4-(1-methyl-4-piperidinylidene)-10H-benzo(4,5)cyclohepta(1,2-b)thiophen-10-one
  • 4-(1-Methyl-4-piperidinylidene)-4H-benzo[4,5]cyclohepta[1,2-d]thiophene-10(9H)-one
  • Brn 3983897
  • Hc 20-511
  • Hsdb 7283
  • Ketotifen Free Base
  • Ketotifen [INN:BAN]
  • Ketotifene
  • Ketotifene [INN-French]
  • See more synonyms
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Found 7 products.